摘要
韧带组织血供少 ,损伤后很难完全愈合 ,造成关节功能严重障碍。组织工程学的发展为韧带损伤的治疗提供了新的可能途径。本文对组织工程韧带领域中目前研究的主要成果进行综述 ,着重就组织工程韧带种子细胞的选择、生长因子的应用、支架材料的选择以及细胞与支架材料之间的相互作用四个方面进行了阐述。目前的研究虽取得了一些进展 ,但仍需在构建有良好力学性能和降解性能支架材料、设计制造能对韧带细胞进行三维培养的生物反应器等方面进行大量研究。
Ligament injury always has an unsatisfied outcome because of the poor blood supply and scar tissue formation. This may result in severe joint dysfunction. Tissue engineering,as a most prospective field,may provide an effective approach for the treatment of ligament injury. This paper has reviewed some recently published articles focusing on the sources of seed cells in ligament tissue engineering,application of growth factors,screening of scaffold materials with specific mechanical and biodegradable properties,and interaction between cells and scaffold materials. At present,what should be extensively studied are scaffolds with specific mechanical and biodegradable properties,and bioreactors providing three-dimensional culture microenvironment mimic in vivo.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2004年第4期674-676,共3页
Journal of Biomedical Engineering
基金
中法先进研究计划生物医学领域项目 ( PRA B0 3 -0 3 )
