摘要
目的关于骨桥蛋白(osteopontin,OPN)与P21蛋白相互关系的研究较少。本研究的目的是探讨OPN与P21在非小细胞肺癌中的表达及其相互关系。方法应用免疫组织化学技术检测58例非小细胞肺癌组织中OPN、P21的表达水平,以18例肺炎性假瘤作为对照。结果非小细胞肺癌组织中OPN和P21阳性表达率分别为58.6%和70.7%,显著高于肺炎性假瘤(11.1%和16.7%)(P=0.0008,P<0.0001)。非小细胞肺癌组织中OPN与P21的表达呈正相关(P<0.0001)。OPN的表达与非小细胞肺癌淋巴结转移有密切关系(P=0.0367),而P21与淋巴结转移未见明显关系(P=0.4898)。结论OPN、P21在非小细胞肺癌中的异常表达有一定协同作用。OPN对提示非小细胞肺癌的转移倾向有一定临床意义。
Background and objective At present, little is known about the correlation between osteopontin (OPN) and P21 in primary non-small cell lung cancer (NSCLC). The aim of this study is to investigate the expression of OPN and P21 and their correlation in NSCLC. Methods The expression of OPN and P21 was detected in 58 NSCLC tissues and 18 pulmonary inflammatory pseudotumor (PIP) as controls by immunohistochemical technique. Results The positive rate of OPN and P21 in NSCLC was 58.6% and 70.7% respectively, which was significantly higher than those in PIP (11.1% and 16.7%) (P=0.0008, P<0.0001). There was a positive correlation between OPN and P21 expression (P<0.0001). Lymph node metastasis was closely related to OPN expression (P=0.0367), but not to P21 expression (P=0.4898). Conclusion The abnormal expression of OPN and P21 in NSCLC may act in a synergistic way. Immunopositivity of OPN may suggest a potential risk of metastasis in NSCLC.
出处
《中国肺癌杂志》
CAS
2007年第4期288-290,共3页
Chinese Journal of Lung Cancer
