摘要
目的研究骨桥蛋白(osteopontin,OPN)、survivin及bcl-2在宫颈病变中的表达及其临床意义。方法应用免疫组织化学SP法,检测74例宫颈癌、20例高级别上皮内瘤变、20例低级别上皮内瘤变以及24例慢性宫颈炎组织中OPN、survivin、bcl-2的表达。结果 OPN、survivin、bcl-2在四组中阳性率的表达差异均有统计学意义(P<0.01)。组间分析显示宫颈癌、高级别上皮内瘤变、低级别上皮内瘤变与慢性宫颈炎相比,三者阳性率的表达差异均有统计学意义(P<0.05)。低级别上皮内瘤变与宫颈癌之间差异有统计学意义(P<0.05),而高级别上皮内瘤变与宫颈癌之间差异无统计学意义(P>0.05)。OPN的表达与sur-vivin、bcl-2的表达呈正相关(P<0.01)。OPN、survivin的表达与宫颈癌组织学分级、FIGO分期和淋巴结转移呈正相关(P<0.05)。结论 OPN在宫颈癌中高表达,提示OPN与宫颈癌的发生、发展密切相关。宫颈上皮内瘤变及宫颈癌组织中OPN的表达与survivin、bcl-2的表达密切相关。
Objective To study the expressions and clinical significance of osteopontin（OPN）, survivin,bcl- 2 in cervical intraepithelial neoplasia（CIN） and cervical carcinoma. Methods By immunohistochemystry method（S-P） ,the expressions of OPN, survivin and bcl-2 in 74 cases of cervical carcinoma,20 cases of high grade CIN （H-CIN）,20 cases of low grade CIN（L-CIN） and 24 cases of chronic cervicitis were ex- amined. Results The expressions of OPN,survivin and bcl 2 were obvious difference among four groups （P〈0.01）. And there was obvious difference between cervical carcinoma, H-CIN, L-CIN and chronic cer- vicitis （P〈0. 05）. There was statistically significant correlation between L-CIN and cervical carcinoma （P〈0.05）, but not H-CIN and cervical carcinoma （P〉0.05）. The expression of OPN was positively as- sociated with survivin, bcl-2（P〈0.01）, and it was also positively associated with differentiated grade, FI- GO staging and lymph nodal involvement （P〈0.05）. Conclusion OPN was more highly expressed in cervical carcinomas, which suggested that OPN was intimately correlated with growth and development of cervical carcinoma. And there was intimate correlation between the expression of OPN and survivin, bcl-2 in cervical intraepithelial neoplasia and cervical carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第1期83-86,共4页
Cancer Research on Prevention and Treatment
关键词
骨桥蛋白
生存素
BCL-2
宫颈癌
宫颈上皮内瘤变
Osteopontin
survivin
bcl-2
Cervical carcinoma
Cervical intraepithelial neoplasia
