摘要
目的观察P21、CDK6在宫颈鳞状细胞癌中的表达情况,探讨其与宫颈鳞状细胞癌的关系。方法采用免疫组织化学ABC法检测100例宫颈鳞状细胞癌、20例宫颈上皮内瘤变(CIN)及20例正常宫颈组织中P21及CDK6的表达情况,分析他们与癌组织分化程度、浸润深度、淋巴结转移及临床分期的关系。结果宫颈鳞状细胞癌组织的P21及CDK6表达率均明显高于CIN组及正常组;P21的低表达与肿瘤浸润深度、淋巴结转移及临床分期(P<0.05)有关,与肿瘤分化程度(P>0.05)无关;CDK6的高表达与肿瘤分化程度、浸润深度、淋巴结转移及临床分期(P<0.05)均有关。结论 P21及CDK6表达异常可能在宫颈鳞状细胞癌的发生、发展中起重要作用;且二者对判断宫颈鳞状细胞癌的预后有一定意义。
Objective To observe the expression of P21 and CDK6 in cervical squamous cell carcinoma,and to investigate the relationship between their expression and cervical squamous cell carcinoma. Methods The expression of CDK6 and P21 in 100 cases of cervical squamous cell carcinoma, 20 cases of cervical CIN lesions and 20 cases of normal cervical tissues were detected by immunohistochemical ABC method,and the relationship between them and tumor differentiation, invasion depth, lymph node metastasis and clinical stage were analyzed. Results The expression rates of P21 and CDK6 in cervical squamous cell carcinoma tissues were significantly higher than those in CIN lesions and normal cervical tissues;The low expression of P21 was associated with the depth of tumor invasion,lymph node metastasis and clinical stage （P〈0. 05） ,and was not associated with the degree of tumor differentiation （P〈0.05） ;The high expression of CDK6 was associated with tumor differentiation,invasion depth,lymph node metastasis and clinical stage （P〈0.05）. Conclusion The abnormal expression of P21 and CDK6 may play an important role in the occurrence and development of cervical squamous cell carcinoma,and the two may have a certain significance in the prognosis of cervical squamous cell carcinoma.
作者
刘静
江叶
闵敏
许建琼
袁华
曾淋
宋大萍
Liu Jing Jiang Ye Min Min Xu Jianqiong Yuan Hua Zeng Lin Song Oaping(Department of Pathology, the Third PeopleZs Hospital of Mianyang city ,Mianyang, Sichuan 621000)
出处
《重庆医学》
CAS
北大核心
2017年第23期3231-3233,共3页
Chongqing medicine
关键词
P21
细胞周期蛋白依赖激酶6
宫颈肿瘤
肿瘤
鳞状细胞
P21 protein
cyclin-dependent kinase 6
uterine cervical neoplasms
neoplasms, squamous cell
