Background:In order to collect and analyze the literature on yellowish leucorrhea disease in Chinese Medical Canon,and to explore its treatment and medication law with data mining.Methods:The Chinese Medical Canon was...Background:In order to collect and analyze the literature on yellowish leucorrhea disease in Chinese Medical Canon,and to explore its treatment and medication law with data mining.Methods:The Chinese Medical Canon was used as the data retrieval source,and“Huangdai”(yellowish leucorrhea disease)and and other keywords were used as the keywords to do literature search.After excluding“gestational yellowish leucorrhea”,“jaundice and yellowish leucorrhea”and other diseases,the literature retrieval and data sorting and analysis were carried out,and the database was established by using Microsoft Excel 2010.Descriptive statistical method was used to analyze the nature,flavour,channel tropism and efficacy of medicine.Combined with the method in“the Research Platform for Inheritance of Traditional Chinese Medicine Academic Thoughts of Famous Gynecologists of Traditional Chinese Medicine”,the association rules between drugs were analyzed and their rules were excavated.Results:Eighty-seven prescriptions,152 traditional Chinese medicines,20 core drug pairs,39 common drug combinations and 5 core drug groups were collected and included.Conclusion:“Damp-Heat”is the fundamental pathological product of yellowish leucorrhea disease,and the basic treatments are“Releasing Heat”and“Eliminating Dampness”,“Regulating Liver Qi”and“Promoting Blood Circulation”,and“strengthening spleen”and stopping leucorrhea.展开更多
Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The f...Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The formulations for leucorrhea were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for leucorrhea were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating leucorrhea with TCM were dissected based on the data of frequency.Results:For 373 kinds of Chinese medicines retrieved from 236 TCM prescriptions,the total medication frequency was 2522.Chinese Angelica(Angelicae Sinensis Radix),White Peony Root(Paeoniae Radix Alba),Indian Buead Tuckahoe(Poria),Common Oyster Shell(Ostreae Concha),and Largehead Atractylodes Rhizome(Atractylodis Macrocephalae Rhizoma)were high-frequency medicines for leucorrhea.Tonic,heat-clearing,and qi-regulating medicines had a high frequency of usage.According to a formula-based analysis of the evidence,the main syndromes of leucorrhea included liver qi affecting the spleen pattern,damp heat accumulation pattern,liver qi stagnation pattern,liver-stomach disharmony pattern,yin deficiency of the liver and kidney pattern,and spleen deficiency with dampness pattern,which are generally in line with the etiology and pathogenesis of leucorrhea,namely pathogenic dampness as the detrimental factor together with spleen-kidney dysfunction.However,in ancient books,emphasis was laid out on the regulation of the liver.This study determined 31 association rules for treating leucorrhea,where the primary compatible medicines contained Chinese Angelica(Angelicae Sinensis Radix)-Nutgrass Galingale Rhizome(Cyperus rotundus),Chinese Angelica(Angelicae Sinensis Radix)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Adhesive Rehmannia Root Tuber(Rehmanniae Radix)and Tangerine Peel(Citri Reticulatae Pericarpium)-Ternate Pinellia(Rhizoma Pinelliae).Conclusion:The medication rules targeting leucorrhea in the Chinese Medical Code were mainly represented by the regulation of qi and blood,as well as the 3 internal organs-the kidney,spleen,and liver.展开更多
盆腔炎性疾病后遗症(Sequelae of pelvic inflammatory diseases,SPID)是常见的妇科慢性疾病,严重影响患者的生活质量以及心理健康。现代医学治疗该病存在较大的局限性,无法有效缓解后遗症期症状。裘氏妇科认为“正虚邪实,湿热瘀结”为...盆腔炎性疾病后遗症(Sequelae of pelvic inflammatory diseases,SPID)是常见的妇科慢性疾病,严重影响患者的生活质量以及心理健康。现代医学治疗该病存在较大的局限性,无法有效缓解后遗症期症状。裘氏妇科认为“正虚邪实,湿热瘀结”为该病核心病机,以“整体论治,扶正祛邪,内外合治”为核心治法,以二藤汤为基础方剂,临床已运用80余载,疗效显著。现总结既往诊疗经验,结合现代研究,为SPID的规范化中医药治疗方案提供理论依据。展开更多
基金This study was supported by Tianjin Health and Family Planning Commission integrated Traditional Chinese and Western medicine research project(2017134).
文摘Background:In order to collect and analyze the literature on yellowish leucorrhea disease in Chinese Medical Canon,and to explore its treatment and medication law with data mining.Methods:The Chinese Medical Canon was used as the data retrieval source,and“Huangdai”(yellowish leucorrhea disease)and and other keywords were used as the keywords to do literature search.After excluding“gestational yellowish leucorrhea”,“jaundice and yellowish leucorrhea”and other diseases,the literature retrieval and data sorting and analysis were carried out,and the database was established by using Microsoft Excel 2010.Descriptive statistical method was used to analyze the nature,flavour,channel tropism and efficacy of medicine.Combined with the method in“the Research Platform for Inheritance of Traditional Chinese Medicine Academic Thoughts of Famous Gynecologists of Traditional Chinese Medicine”,the association rules between drugs were analyzed and their rules were excavated.Results:Eighty-seven prescriptions,152 traditional Chinese medicines,20 core drug pairs,39 common drug combinations and 5 core drug groups were collected and included.Conclusion:“Damp-Heat”is the fundamental pathological product of yellowish leucorrhea disease,and the basic treatments are“Releasing Heat”and“Eliminating Dampness”,“Regulating Liver Qi”and“Promoting Blood Circulation”,and“strengthening spleen”and stopping leucorrhea.
基金This study was supported by a grant from the China Academy of Chinese Medical Sciences(No.C12021A00404).
文摘Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The formulations for leucorrhea were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for leucorrhea were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating leucorrhea with TCM were dissected based on the data of frequency.Results:For 373 kinds of Chinese medicines retrieved from 236 TCM prescriptions,the total medication frequency was 2522.Chinese Angelica(Angelicae Sinensis Radix),White Peony Root(Paeoniae Radix Alba),Indian Buead Tuckahoe(Poria),Common Oyster Shell(Ostreae Concha),and Largehead Atractylodes Rhizome(Atractylodis Macrocephalae Rhizoma)were high-frequency medicines for leucorrhea.Tonic,heat-clearing,and qi-regulating medicines had a high frequency of usage.According to a formula-based analysis of the evidence,the main syndromes of leucorrhea included liver qi affecting the spleen pattern,damp heat accumulation pattern,liver qi stagnation pattern,liver-stomach disharmony pattern,yin deficiency of the liver and kidney pattern,and spleen deficiency with dampness pattern,which are generally in line with the etiology and pathogenesis of leucorrhea,namely pathogenic dampness as the detrimental factor together with spleen-kidney dysfunction.However,in ancient books,emphasis was laid out on the regulation of the liver.This study determined 31 association rules for treating leucorrhea,where the primary compatible medicines contained Chinese Angelica(Angelicae Sinensis Radix)-Nutgrass Galingale Rhizome(Cyperus rotundus),Chinese Angelica(Angelicae Sinensis Radix)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Adhesive Rehmannia Root Tuber(Rehmanniae Radix)and Tangerine Peel(Citri Reticulatae Pericarpium)-Ternate Pinellia(Rhizoma Pinelliae).Conclusion:The medication rules targeting leucorrhea in the Chinese Medical Code were mainly represented by the regulation of qi and blood,as well as the 3 internal organs-the kidney,spleen,and liver.
文摘盆腔炎性疾病后遗症(Sequelae of pelvic inflammatory diseases,SPID)是常见的妇科慢性疾病,严重影响患者的生活质量以及心理健康。现代医学治疗该病存在较大的局限性,无法有效缓解后遗症期症状。裘氏妇科认为“正虚邪实,湿热瘀结”为该病核心病机,以“整体论治,扶正祛邪,内外合治”为核心治法,以二藤汤为基础方剂,临床已运用80余载,疗效显著。现总结既往诊疗经验,结合现代研究,为SPID的规范化中医药治疗方案提供理论依据。
