This letter addresses the study in recent publication in the World Journal of Diabetes.The study provides valuable insights and a comprehensive analysis of the effects of L-arginine(L-Arg)supplementation on cardiac he...This letter addresses the study in recent publication in the World Journal of Diabetes.The study provides valuable insights and a comprehensive analysis of the effects of L-arginine(L-Arg)supplementation on cardiac health in diabetic rats,highlighting the potential risks associated with high doses of L-Arg.The findings suggest that while low doses of L-Arg may offer some benefits,higher doses can exacerbate myocardial injury through increased oxidative stress,in-flammation,and structural disruption.This finding challenges the prevailing point of L-Arg as a universally beneficial supplement and emphasizes the need for further research in its clinical application,particularly in diabetic patients.展开更多
基金Supported by National Natural Science Foundation of China,No.81670747Huangshi Municipal Health Commission Key Projects,No.WJ2024006.
文摘This letter addresses the study in recent publication in the World Journal of Diabetes.The study provides valuable insights and a comprehensive analysis of the effects of L-arginine(L-Arg)supplementation on cardiac health in diabetic rats,highlighting the potential risks associated with high doses of L-Arg.The findings suggest that while low doses of L-Arg may offer some benefits,higher doses can exacerbate myocardial injury through increased oxidative stress,in-flammation,and structural disruption.This finding challenges the prevailing point of L-Arg as a universally beneficial supplement and emphasizes the need for further research in its clinical application,particularly in diabetic patients.
