期刊文献+

饲喂外源性DNA对小鼠体内LPO和Lf生成的影响

Effects of DNA on Producing of PLO and Lf in mice
在线阅读 下载PDF
导出
摘要 目的 :探讨外源性DNA对体内LPO和Lf生成的影响。方法 :分别用外源性DNA和VE定时定量喂养小鼠 ,测定和比较小鼠体内LPO、Lf含量变化。结果 :外源性DNA与VE一样 ,有效地降低了小鼠体内LPO、Lf含量 ,对肝、心脏的作用较对脑组织明显 ,高剂量DNA抑制效果强于低剂量DNA。结论 :外源性DNA具有抗氧化剂的作用 ,对动物体内LPO。 Objective:To explore the effects of deoxyribonucleic acid on the producing of lipid peroxides (LPO) and lipofascin (LF).Method:DNA and VE were fed separately to the young mice at regular time and ration,the changes of LPO and Lf contents were determined.Results:DNA just as VE reduced the contents of LPO and Lf effectively,the effects on liver and heart is more obviously than on brain, and a high dose of DNA plays a more obvious inhibiting role than a low dose.Conclusion:DNA has the same function as VE, which plays an obvious inhibiting role in the producing of LPO and LF.
出处 《生物技术》 CAS CSCD 2004年第3期60-62,共3页 Biotechnology
关键词 过氧化脂质 脂褐素 脱氧核糖核酸 自由基 丙二醛 lipid peroxides (LPO) lipofascin (LF) deoxyribonucleic acid free radicals malondilldhyde
  • 相关文献

参考文献8

二级参考文献20

  • 1董再珍,王龙,章君照.核酸对机体作用的研究[J].中国药学杂志,1995,30(12):725-727. 被引量:22
  • 2MEDVEDEV Z A. An attempt at a rational classification of theories of aging[J], Biol Rev, 1990,65: 375-398.
  • 3FINCH C E, TANZI R E. Genetics of aging[J]. Science, 1997, 278: 407-411.
  • 4de LANGE T. Telomeres and senescence: ending the debate[J]. Science, 1998, 279:334-335.
  • 5CUTLER R G. Longevity determinant genes, cellular dysdifferentiation and oxidative stress[A].CUTLER R G. PACKER L, BERTRAM J, el al. Oxidative Stress and Aging[C]. Switzerland: Birkhauser Verlag, 1995. 15-19.
  • 6HARMAN D. Aging: a theory based on free radical and radiation chemistry[J]. J Gerontol, 1956,22: 289-300.
  • 7YU B P. Aging and oxidative stress: modulation by dietary restriction[J]. Free Rod Biol Mod, 1996,21: 652-668.
  • 8BAYNES J W, THORPE S R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm[J]. Diabetes, 1999, 48: 1-9.
  • 9LITCHFIELD J E, THORPE S R, BAYNES J W. Oxygen is not required for the browning and crosslinking of protein by pentoses: relevance to Maitlard reactions in vivo[J]. Int J Biocem Cell Bol, 1999,31: 1297-305.
  • 10YIN D, BRUNK U F. Carbonyl toxification hypothesis of biological aging[A]. MACIEIRA-COELHO A. Molecular Basis of Aging[C]. New York: CRC Press Inc, 1995. 421-436.

共引文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部