摘要
目的探讨负性情绪对银屑病患者病程影响的分子病理学基础。方法用免疫组化法(SABC法)检测银屑病患者皮损中神经生长因子(NGF)的2个受体p75和p140trkA表达情况,同时应用焦虑自评量表(SAS)和抑郁自评量表(SDS)对患者进行问卷测评,并进行相关性统计学处理。结果银屑病患者的负性情绪(焦虑与抑郁)程度与2个神经生长因子受体表达呈正相关。结论NGF及其受体是负性情绪影响银屑病患者病情活动程度的重要中介物质。
Objective To investigate the molecular mechanism of mood disorders in psoriatic patients.Methods The expression of nerve growth factor receptor p75(NGFR p75)and p140trkA were detected by immunohistochemical technique.The patients' mood was measured with self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Results There is a positive correlation of the expressions of NGFR p75and p140trkA with the patients' mood disorders in psoriatic patients.Conclusion NGF and its receptors are the important substance served as a mediator of the mood disorders affecting psoriatic patients' condition.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2004年第3期141-143,共3页
Chinese Journal of Dermatology
基金
广东省重点科技攻关项目(99050)
