摘要
目的探讨竹黄颗粒剂II号治疗寻常性银屑病作用机制。方法采用免疫组化ABC法检测患者口服竹黄颗粒剂II号前、后皮损中MMP2和TIMP2阳性强度,并与银屑灵冲剂组对照。结果治疗后两组患者皮损MMP2和TIMP2阳性水平均显著下降(P均<0.01);且竹黄组优于银屑组(P<0.05)。结论竹黄颗粒剂II号是治疗寻常性银屑病的有效复方,显著降低寻常性银屑病患者皮损中MMP2和TIMP2的阳性水平可能是其作用机制之一。
Objective To explore the therapeutic mechanism of Zhuhuang Granule II. Methods To compare MMP 2 and TIMP 2 detection in the lesions of patients with immunohistochemical technique Avidin Biotin comples (ABC) before and after treatment,and 15 normal controls.Results The MMP 2 and TIMP 2 of all cases in both of the ZHG II group and Yinxie group decreased after treating,but the improvement in ZHG II group was more remarkable than that in Yinxie group( P <0.01).Conclusion These functions are partially effective mechanism of ZHG II.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2004年第11期662-664,共3页
The Chinese Journal of Dermatovenereology
