摘要
目的 :探讨国产生物降解泌尿系支架材料己内酯 /还氧乙烷共聚物 (PCL- EO)的生物相容性及体内、体外降解特性。方法 :将 PCL- EO试件埋植在 Wistar大鼠脊柱两侧肌肉内或浸泡于流动的尿液中 ,分别于 2、 4、6、 8、 1 0、 1 2、 1 4及 1 6周取出 ,通过组织病理学切片研究材料周围组织反应 ,利用扫描电镜检查和分子量、重量检测以了解 PCL- EO在体内、体外的降解情况。结果 :PCL- EO材料在 1 6周内可降解为随尿液流动的细小颗粒。材料的体内、体外降解趋势相同 ,体内降解速度略快于体外降解。埋植材料周围肌肉组织无脓肿形成和组织坏死发生 ,局部组织反应为非细菌性炎症反应。结论 :PCL- EO材料生物相容性良好 ,降解时间适宜 ,适用于制备泌尿系支架 。
Objective To study the biocompatibility and biodegradation characteristics of poly(caprolactone b ethylene oxide) (PCL EO), a kind of biodegradable material, used for urological stent in vivo and in vitro . Methods Pellets made from PCL EO were implanted in the dorsal muscle of Wistar rats or dipped into flowing urine. Tissue blocks surrounding the biomaterials and the PCL EO pellets were took out after 2, 4, 6, 8, 10, 12, 14 and 16 weeks, respectively. Histological study was taken to investigate the tissue reaction of the material and evaluate its biocompatibility. Scanning electron microscopy (SEM) and measurement of molecular weight and gravity were used to make out the biodegradation characteristics of PCL EO both in vivo and in vitro . Results The PCL EO test pieces degraded into small particles that could be excreted with the urine flow after 16 weeks. The biodegradation pattern in vivo was similar to that in vitro . There was no abscess formation and tissue necrosis surrounding the implanted materials. Non infectious reactions due to materials implanted were observed. Conclusion The biodegradable material PCL EO has good biocompatibility and appropriate biodegradation characteristics and will meet the request for urological stent.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2004年第3期362-365,F003,共5页
Journal of Jilin University：Medicine Edition
关键词
生物相容性材料
生物降解
泌尿道
支架
biocompatible materials
biodegradation
urinary tract
stents
