摘要
目的 探讨原发性高血压患者血管内皮功能损伤、血栓前状态及两者间的关系。方法 对原发性高血压Ⅰ级 (n =2 0 )、Ⅱ级 (n =2 0 )患者及正常人 (n =2 0 )采用高分辨率超声技术检测血流介导的肱动脉舒张功能(FMD) ,并分别测定血清一氧化氮 (NO)水平和血浆血栓素B2 (TXB2 )和 6 -酮 -前列腺素 1a(6 -K -PGF1a)水平 ,并进行相互比较。结果 与正常对照组比较 ,原发性高血压Ⅰ级、Ⅱ级患者血浆TXB2 的水平明显升高 ,差别有统计学意义 (P <0 .0 5 ) ,FMD、NO、6 -K -PGF1a水平明显下降 ,差别有统计学意义 (P <0 .0 5 ) ;与原发性高血压Ⅰ级组比较 ,原发性高血压Ⅱ级组TXB2 的水平明显升高 ,差别有统计学意义 (P <0 .0 5 ) ,FMD、NO、6 -K -PGF1a水平明显下降 ,差别有统计学意义 (P <0 .0 5 ) ;经直线相关分析显示 :血清NO、FMD与血浆 6 -K -PGF1a呈正相关 (P <0 .0 5 ) ,血清NO、FMD与血浆TXB2 呈负相关 (P <0 .0 5 )。结论 原发性高血压患者血管内皮明显受损 ,存在血栓前状态 ,可能是血栓性疾病如急性心梗、脑卒中发生的机制 ,将有助于对高血压患者心血管事件的预测。
Ojective To discuss the endothelium dependent vasodilatation、 prethrombotic state and the relationship of both with essential hypertensive patients. Methods With high-resolution ultrasound flow induced dilation of the brachial artery(FMD) was measured in essential hypertension Ⅰgrades (n=20)、Ⅱgrades (n=20)and 20 health person of control group. Both serum nitric oxide (NO) and plasma thromboxane B 2 (TXB 2) 、6-K-PGF1a were assayed at the same time. Result TXB 2 in hypertention Ⅰgrades (n=20)、Ⅱgrades (n=20)was found significantly higher than that in the control group( P<0.05 ); FMD、NO、6-K-PGF1a in hypertention Ⅰgrades (n=20)、Ⅱgrades (n=20)was found significantly lower than that in the control group( P<0.05). FMD、NO、6-K-PGF1a in hypertention Ⅱ grades was found significantly lower than that hypertention Ⅰgrades( P<0.05 ).There is a significantly correction between the serum NO、FMD and the plasma 6-K-PGF1a(P< 0.05 ). Conclusion Essential hypertensive patients had endothelium dependent vasodilatation dysfunction 、platelet action ,which may be the pathogenesis of complication such as ischemic stroke、heart attacks. These findings might help identify hypertensive patients who are at increased risk of cardiovascular events.
出处
《苏州大学学报（医学版）》
CAS
2004年第2期195-198,共4页
Suzhou University Journal of Medical Science
关键词
原发性高血压
内皮依赖性舒张功能
一氧化氮
血栓前状态
essential hypertention
endothelium dependent vasodilatation
nitric oxide
prethrombotic state
