摘要
目的 :探讨高血压病易并发血栓性疾病的机制。方法 :分别采用放射免疫法、发色底物显色法、ELISA法等检测 16例健康人 (对照组 )、5 3例高血压病 1、2、3级患者血浆中的分子标志物—血栓素B2 (TXB2 )、6 -酮前列腺素F1α(6 -K -PGF1α)、组织型纤溶酶原激活物 (t-PA)、组织型纤溶酶原激活物抑制物 (PAI- 1)及血液流变学指标。结果 :1～ 2级高血压组及 3级高血压组病人 ,血浆TXB2 、t-PA含量、PAI- 1含量及活性、血粘度、纤维蛋白原水平均明显高于对照组 (P <0 .0 5 ) ;而t-PA活性、6 -K -PGF1α含量均显著下降 (P <0 .0 5 )。结论 :高血压病患者存在血栓前状态 ,血压升高可能是直接原因。这为解释及防治高血压病血栓性并发症提供了依据。
Objective:To investigate the mechanism of thrombotic complications in hypertensive patients.Methods: A series of molecular markers,that is,thromboxane B 2(TXB 2)?6-keto-prostaglandin F 1α (6-K-PGF 1α ) ,tissue-type plasminogen activator (t-PA) and its inhibitor(PAI-1)were measured in 53 patients with 1st,2nd and 3rd degree of essential hypertension and 16 normotensive controls by the radioimmunoassay,the chromogenic substrate and the enzyme linked immunosorbent assay(ELISA) respectively .The indexes of hemorheology were also studied in these subjects.Results: As compared with controls,plasma levels of TXB 2?t-PA antigen?PAI-1antigen and activity ,blood viscosity and plasma fibrinogen were found significantly higher(P<0.05) in hypertensive patients;but t-PA activity,and 6-k-PGF 1α were lower(P<0.05).Conclusion:Prethrombotic state is present in hypertensive patients and probably releated to increased blood pressure.This explains in part why the thrombotic complications are common in hypertensive patients and provides theoretic supports for therapy of the disease.
出处
《泸州医学院学报》
2002年第3期189-192,共4页
Journal of Luzhou Medical College
