摘要
研究长期游泳运动对高血压血小板L-Arg/NO系统的影响及作用机制。对18只雄性自发性高血压大鼠(SHR)进行随机分组:对照组C(8只)和运动组T(10只)。10周游泳运动后,分别测定SHRPAG(M)、血小板NO含量、血小板NOS活性和血小板内cGMP水平。结果表明:与对照组相比,运动组SHRADP(2μmol/L)诱导PAG(M)显著下降,血小板NO含量升高,血小板NOS活性上升,血小板内cGMP水平上升,且均存在显著性差异。提示,进行长期中等强度运动能改善高血压大鼠血小板L-Arg/NO系统的功能来抑制血小板的聚集,对防治高血压血栓性疾病有重要的作用。
This paper investigated the effect and functional mechanism of long-term swimming exercise on platelets L-Arg/NO pathway in hypertension. 18 male SHR are randomly divided into two groups,control group C （n=8） and exercise group T （n=10）.After ten weeks of swimming exercise, the ADP （ 2μmol/L ） induced platelet maximal aggregation, the concentration of platelet-derived nitric oxide （platelet-derived NO）,platelet NOS activity and intraplatelet levels of cGMP were measured. The result showed that the ADP induced PAG （M） was significantly decreased and the concentration of platelet-derived NO,the activity of NOS in platelet and intraplatelet levels of cGMP were significantly increased in exercise group comparing with control group. It suggested that long-term moderate exercise intensity could improve the platelets L-Arg/NO pathway in SHR, had important influence in preventing thrombosis in hypertension.
出处
《体育科学》
CSSCI
北大核心
2005年第9期56-58,共3页
China Sport Science
关键词
运动
高血压
血小板
血栓
鼠
动物实验
exercise
hypertension
platelet
rat
animal experiment
