摘要
目的:探讨血管紧张素转换酶抑制剂洛汀新对原发性高血压(EH)患者的降压作用及其对NO和NOS水平的影响。方法:采用每日1次洛汀新10 mg治疗EH患者(21例)8周,观察治疗前、后血压和血小板(Pt)NO水平及NOS活性的变化。结果:EH患者Pt的NOS活性和NO水平显著低于正常对照组(14例)(P<0.01)。经洛汀新治疗后EH患者的血压显著降低(P<0.01),Pt的NO产生量及NOS活性显著升高(P<0.01)。结论:洛汀新可降低血压、调节血小板NOS的活性和NO分泌量。
AIM： To investigate the effect of ACEI （ Lotensin ） on blood pressure （ BP ）, NO production and NOS activity in patients with essential hypertension （EH）. METHODS： 21EH patients were treated with Lotensin everyday for 8 weeks. Before and after the treatment, the BP level, the NO production and NOS activity were measured. RESULTS ： In EH patients, the production of NO and the activity of NOS were significantly lower than those in normal （ P 〈 0.01）. After the treatment of ACEI, blood pressure decreased significantly, the NO production and NOS activity increased significantly （ P 〈 0.01 ）. CONCLUSION ： ACEI （Lotension） has antihypertensive NO production of platelet in EH patients. effect, simultaneously, it increases NOS activity and NO production of platelet in EH patients.
出处
《心脏杂志》
CAS
2005年第4期371-372,375,共3页
Chinese Heart Journal
