摘要
在显微电视放大4000倍条件下观察了烧伤休克早期大鼠脊斜肌微循环变化,并用病理切片观察了肺内病变程度。结果表明,烧伤休克时虎杖4号可明显减少白细胞附壁粘着,毛细血管开放数增多,同时肺内白细胞聚集和损伤亦明显减轻,动物存活时间明显延长。
A model of burn shock was reproduced in rat.The effects of crystal No 4 of Polygonum cuspidatum (p.c.) on microcirculation of spinotrapezius muscle in rat with burn shock were observed with a special Hitachi TV set with magnification of 4000x.The changes in water content in tissues of lung and burned skin were measured.The survival time of burned animals was recorded.The aggregation of WBC and the degree of tissue damage in lung were examined in pathologic slides.The results showed that during barn shock the number of adhesive WBC in venules was about 8 times more than normal,the amount of open capillaries was reduced by 3/5 of normal.There were apparent aggregation of WBC and tissue damage in the lung. The number of adhesive WBC was decreased by 80%,the amount of open capillary returned to near normal,and the aggregation of WBC and the degree of tissue damage in the lung were alleviated by administration of crystal No 4 of Polygonum cuspidatum.The survival time in p.c.-treated group was prolonged 1.9-fold of that in n.s.-treated group.The results indicated that the decrease of WBC adherence was caused by,on the one hand,the increase of driving force and wall stress after treatment of p.c.,and on the other hand,p.c.might affect some humoral factors which promoted WBC adherence.
