摘要
目的 :定量检测前列腺疾病患者血清中胰岛素样生长因子 - 1 (IGF - 1 )、前列腺特异性抗原 (PSA)和游离前列腺特异性抗原 (fPSA)的含量并探讨其在前列腺疾病的诊断作用。方法 :采用放射免疫分析法 (RIA)和微粒子化学发光法对 4 1例前列腺癌 (PCa) ,6 2例良性前列腺增生 (BPH)患者和4 8例健康男性 (正常对照组 )血清中IGF - 1、PSA和fPSA进行定量检测。结果 :前列腺癌患者血清中IGF - 1、PSA、fPSA的含量明显高于BPH组和正常对照组 (P <0 .0 5 ) ,IGF - 1在前列腺癌的发展过程中有增高趋势 ,但各分期没有统计学意义 (P >0 .0 5 ) ;BPH组与正常对照组之间比较差异无显著性 (P >0 .0 5 ) ,但IGF - 1水平随前列腺增生体积 (PV)的增加而有所升高。结论 :IGF - 1的高低与前列腺增生程度有关 ;IGF - 1水平的升高可能增加前列腺癌的危险性。
Objective: To quantify the levels of insulin-like growth factor-1(IGF-1),PSA,fPSA in serum and investigate its role in the diagnosis of prostate cancer and benign prostate hypertrophy.Methods:IGF-1 were determined by radioimmunoassay(RIA)and PSA,fPSA were determined by IMMULITE analyzer in patients with prostate cancer(n=41),benign prostate hypertrophy (BPH, n=62), and healthy male controls (n=48). Results: There was high level of IGF-1,PSA and fPSA in patients with prostate cancer than those in BPH,and healthy controls(P<0.05),the level of IGF-1 was increased during the development of prostate cancer; there was no significantly in BPH and healthy male controls(P>0.05),but with the increasing of the PV, the level of IGF-1 was increasing.Conclusion: These observations implicated that IGF-1 may important factor in the prostate cancer and BPH.
出处
《河北医学》
CAS
2004年第4期306-308,共3页
Hebei Medicine
