摘要
目的研究血清胰岛素样生长因子(IGF)-1在类风湿关节炎(RA)血管炎发病中的作用。方法应用双抗体夹心酶联免疫吸附试验(ELISA)法测定62例RA患者,30名正常对照组血清IGF-1及肿瘤坏死因子(TNF)-α水平。进一步按外周血血小板计数分为血小板升高组和血小板正常组;按呼吸系统检查情况分为伴肺间质改变及不伴肺间质改变组;并与同时检测的其他免疫学指标进行相关分析。结果RA血小板升高组血清IGF-1为(132±81)ng/ml,血清TNF-α(1.34±0.30)ng/ml;血小板正常组血清IGF-1为(75±79)ng/ml,血清TNF-α(0.96±0.46)ng/ml;伴肺间质改变组血清IGF-1为(155±99)ng/ml,血清TNF-α(1.22±0.57)ng/ml,无肺间质改变组血清IGF-1为(81±62)ng/ml,血清TNF-α(1.09±0.37)ng/ml;正常对照组血清IGF-1及TNF-α水平分别为(37±74)ng/ml和(0.27±0.10)ng/ml。RA组血清IGF-1、TNF-α与正常对照组相比差异有显著性,且两者存在相关关系,血小板升高、伴肺间质改变组血清IGF-1均较血小板正常组及正常对照组增高且有统计学意义。结论提示血清IGF-1在RA伴有血管炎患者中明显升高特别在肺间质性疾病中起重要作用。
Objective To investigate the role of insulin-like growth factor-1 (IGF-1) in the patho-genesis of rheumatoid arthritis (RA) vasculitis. Method Serum samples of IGF-1 and TNF-α from 62 rheumatoid arthritis patients and 30 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA). Patients were divided into different groups according to the amount of platelets in peripherol blood and pulmonary interstitial disease, then the relationship between them and other indexes was analyzed. Results In RA patients with high-platelet, serum IGF-1 was (132+81) ng/ml and TNF-α was (1.34±0.30) ng/ml; in normal-platelet group, serum IGF-1 was (75±79) ng/ml, TNF-α was (0.96±0.46) ng/ml. In RA patients with pulmonary interstitial changes, serum IGF-1 was (155±99) ng/ml and TNF-α was (1.22±0.57) ng/ml; patients without pulmonary interstitial changes, serum IGF-1 was (81±62) ng/ml and serum TNF-α was (1.09±0.37) ng/ml; In health control, serum IGF-1 was (37±74) ng/ml and TNF-α was (0.27±0.10) ng/ml. Serum IGF-1 and TNF-α had significant difference compared with control group. Serum level of IGF-1 correlated with serum TNF-α and showed higher level in RA with high platelet and pulmonary interstitial disease. Conclusion Serum level of IGF-1 is greatly increased in RA patients with vasculitis and plays an important role in the occurrence and development of pulmonary interstitial disease.
出处
《中华风湿病学杂志》
CAS
CSCD
2004年第11期677-680,共4页
Chinese Journal of Rheumatology
