摘要
目的 探讨血清胰岛素样生长因子 1(IGF Ⅰ )与前列腺癌 (PCa)发生发展的关系。 方法 采用免疫放射分析法 (IRMA)检测 3 7例PCa、3 5例良性前列腺增生 (BPH)患者和 2 0例健康人血清IGF Ⅰ ,比较各期PCa血清IGF Ⅰ水平 ,并对 8例行根治性前列腺全切术后患者手术前后IGF Ⅰ水平随访。 结果 PCa组血清IGF Ⅰ ( 3 2 5 .6± 10 0 .8)ng/ml,明显高于BPH组 ( 2 0 1.6± 5 3 .8)ng/ml和健康组 ( 179.0± 5 7.2 )ng/ml,差异有显著性意义 (P <0 .0 1) ;BPH组与健康组比较差异无显著性意义 (P >0 .0 5 ) ;8例PCa患者术前IGF I( 3 15 .8± 87.0 )ng/ml,术后 ( 2 2 4.8± 88.4)ng/ml,差异有显著性意义 (P <0 .0 5 ) ;PCa患者各期血清IGF Ⅰ比较差异无显著性意义 (P >0 .0 5 )。 结论 IGF Ⅰ有可能作为临床上一个新的PCa检测指标预测高危人群 。
Objective To study the relationship between serum insulin-like growth factor-1(IGF-Ⅰ) levels and prostatic cancer. Methods The levels of IGF-Ⅰwas measured with immunoradiometric assay(IRMA) in 37 cases of prostatic cancer,35 cases of benign prostatic hyperplasia (BPH) and in 20 healthy subjects as controls.The serum IGF-I levels were compared to the clinical and pathological grading of the prostatic cancer.8 cases of prostatic cancer after operation have been followed up. Results The mean levels of serum IGF-I in prostatic cancer (325.6±100.8 ng/ml) were significantly higher than those in BPH (201.6±53.8 ng/ml) and healthy subjects (179.0±57.2 ng/ml) (P<0.01).Whereas there were no statistical difference between BPH and healthy subjects(P>0.05).Statistical difference was noted before ( 315.8±87.0 ng/ml) and after (224.8± 88.4 ng/ml) PCa operation(P<0.01),but significant difference among the various stages of PCa has not been observed(P>0.05). Conclusions The levels of serum IGF-I may be a new marker to prognose and for early diagnosis of PCa in high risk population.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2003年第2期117-118,共2页
Chinese Journal of Urology
