期刊文献+

维持性血透患者应用重组人生长激素的意义

Clinical value of recombinant growth hormone therapy in maintenance hemodialysis
暂未订购
导出
摘要 目的 评价维持性血透患者应用重组人生长激素 (rhGH)后营养状态改善的疗效。方法 随机选择 10例血透患者给予rhGH 4IU/m2 ,隔日 1次 ,另 10例未用药的常规血透患者做为对照组。两组血透患者饮食中蛋白质摄入量无明显差别 ,分别检测血中的生长激素 (GH)、血浆胰岛素样生长因子 (IGF -1)及转铁蛋白水平。结果 治疗 3个月后 ,rhGH治疗组的体重有明显增加 (P <0 0 5 ) ,IGF -1水平明显升高 (P <0 0 1) ,血清转铁蛋白水平明显升高 (P <0 0 1)。同时 ,患者血清尿素氮 (BUN)水平有明显下降 (P <0 0 5 )。结论 维持性血透患者短期应用rhGH后能有效改善血透患者的营养状态 。
出处 《广东医学》 CAS CSCD 2001年第3期216-218,共3页 Guangdong Medical Journal
  • 相关文献

参考文献8

  • 1[1]Kopple JD. The rationale for the use of growth hormone or insulin-like growth factor-1 in adult patients with renal failure. Miner Electrolyte Metab, 1992, 18:269
  • 2[2]Iglesias P, Juan J, Die Z, et al. Recominant human growth hormone therapy in malnourished dialysis patients: a randomized controlled study. Am J of Kid Dis, 1998, 454
  • 3[3]Hoffman DM, Crampton L, Sermia C, et al. Short-term growth hormone(GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure. J Clin Endocrinol Metab , 1996, 81:1123
  • 4[4]Merchav S, Tatarsky I, Hochberg Z. Enhancement of erythropoiesis in vitro by human growth hormone is mediated by insulin-like growth factor-1. Br J Haematol , 1988,70:267
  • 5[5]Schulman G, Wingard RL, Hutchison RL, et al. The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis, 1993,21: 527
  • 6[6]Ikizler AT, Wingard RL, Breyer JA,et al. Short-term effects of recominant human growth hormone in CAPD patients. Kidney Int, 1994, 46:1178
  • 7[7]Blum WF. Insulin-like growth factors(IGFs) and IGF bonding proteins in chronic renal failure: evidence for reduced secretion of IGFs. Acta Paediatr Scand, 1991, 379(suppl):24
  • 8[8]Jensen PB, Hansen TB, Frystyk J, et al. Growth hormone, insulin-like growth factors and their binding proteins in adult hemodialysis patients treated with recominant human growth hormone. Clin Nephrol, 1999, 52:103

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部