摘要
绞股蓝总皂甙(50mg·kg^(-1))可明显改善家兔脑缺血60 min后的脑电图变化,降低脑静脉血中LDH和CPK活性,改善缺血后脑组织形态学变化,提示绞股蓝总皂甙对脑缺血有保护作用。
The protective effect of gypenosides (GP) extracted from Gynostemma pentaphyllum (Thunb.) Mak. on acute incomplete cerebral ischemia in rabbits was studied. This ischemia-model was produced by bilateral carotid artery occlusion coupled with hemorrhagic hypotension. 30 rabbits were randomly divided into 3 experimental groups, 10 in each group. Group 1: sham operation; Group 2: ischemia for 60 min; Group 3: GP and ischemia 60 min. GP (50 mg·kg-1) was slowly injected iv 30 min before ischemia. In the ischemia group, normal saline was injected iv in the same volume as GP. By the endof 60 min of induced ischemia, GP significantly improved the brain electrical activity and histological and ultrastructural ischemia changes and suppressed the rise of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) release in the cerebral venous blood. These results indicate that GP has the protective effect on acute cerebral ischemia injury.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1992年第3期204-206,共3页
Chinese Journal of Pharmacology and Toxicology
关键词
绞股蓝皂甙
脑缺血
脑电图
gypenosides cerebral ischemia electroencephalogram lactate dehydrogenasecreatine phosphokinase
