摘要
很多中药有效成分以苷的形式存在,近年来,中药苷类生物利用度低的问题引起了广泛关注。经不同途径给药后苷类及其代谢产物的组织分布情况直接影响其疗效。随着中药苷类用于脑部疾病防治的报道日益增多,苷类的脑组织分布规律研究显得尤为重要。据报道,苷在体内各组织广泛分布,有些苷可以到达脑组织,有些苷却不能进入脑组织。该研究对苷类及其代谢产物对脑部疾病的作用、在脑组织的分布情况和剂型对药物脑组织分布影响的近年报道进行了综述,以期为该类中药在脑部疾病防治中的研究及其新药研发提供一定的参考。
Many active ingredients in traditional Chinese medicine exist in the form of glycosides.In recent years,the problem of low bioavailability of Chinese glycosides has caused wide public concern.Glycosides and their metabolites organization distribution directly affect glycosides' curative effect after different ways administration.With reports of glycosides medicine for prevention and treatment of brain diseases increasing,the research of glycosides brain tissue distribution is particularly important.According to reports,glycosides widely distributed in tissues,some glycosides can reach the brain,but some glycosides can not.This research reviews glycosides and their metabolites on the role of brain diseases,the distribution in the brain tissue and recent reports of dosage form's effect to brain.So it can provide a reference for the period of such medicine in the prevention and treatment of brain diseases and drug development.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第2期152-157,共6页
China Journal of Chinese Materia Medica
基金
中医药行业科研专项(200708006)
国家“重大新药创制”科技重大专项(2009ZX09103-393,2009ZX09310-005)
关键词
中药
苷类
苷元
代谢产物
脑组织
traditional Chinese medicine
glycosides
aglycones
metabolites
brain tissue
