摘要
目的 探讨外周血淋巴细胞中黏附分子CD44在肺癌患者中的表达及其临床意义。方法用流式细胞仪定量检测72例肺癌患者外周静脉血中CD44水平,与正常人及慢性支气管炎患者进行对照,应用统计学分析比较。结果 肺癌组外周血CD44含量为(57.85±1.99),明显高于正常人组(43.03±2.33)(P<0.01)及慢性支气管炎组(45.37±1.79)(P<0.01),CD44的表达水平与患者病理类型不呈相关性(P<0.05),但与临床分期和组织学分级相关(P<0.01或P<0.05)。结论 外周血淋巴细胞中CD44含量可作为肺癌患者诊断的参考指标。
Objective To study the relationship between the expression of CD44 and the histological type,degree of differentiation, and metastasis of non-small cell lung cancer (NSCLC) .Methods Peripheral blood CD44 levels in 72 patients with lung cancer were examined by immune flowcytometry,and compared with those in 39 normal donors and 47 patients with chronic bronchitis as controls,by statistical analysis.Results The CD44 level in patients with lung cancer (57 .85±1. 99) was significantly higher than those in patients with chronic bronchitis (45.37±1.79, P < 0.01) and in normal donors (43.03±2.33, P < 0.01). The expression of CD44 was not related to pathological types, but closely associated with clinical stages and histopathological grades( P < 0.01 or P< 0.05) .Conclusion Peripheral blood CD44 levels in NSCLC can be used as an index for evaluating the diagnosis of NSCLC patients.
出处
《武警医学》
CAS
2004年第3期177-179,共3页
Medical Journal of the Chinese People's Armed Police Force
