摘要
目的 :探讨老年肺癌患者外周血淋巴细胞中粘附分子CD4 4表达及其临床意义。方法 :用流式细胞术定量检测 6 6例老年肺癌患者外周静脉血中CD4 4水平 ,与正常人及慢性支气管炎患者进行相互对照 ,并通过自身对照分析手术前后或化疗前后的变化 ,应用统计学分析比较。结果 :老年肺癌组外周血CD4 4含量为 5 83 5 2± 18 6 4 ,明显高于正常人组 (42 8 37±14 2 5 ,P <0 0 1)及慢性支气管炎组 (44 2 6 3± 15 32 ,P <0 0 1) ,且手术前或化疗前的肺癌患者外周血CD4 4的表达也明显高于手术后或化疗后 (P <0 0 1或P <0 0 5 )。CD4 4的表达水平与患者病理类型不呈相关性 (P >0 0 5 ) ,但与临床分期和组织学分级相关 (P <0 0 1或P <0 0 5 )。结论 :外周血淋巴细胞中CD4 4含量可作为老年肺癌患者诊断的参考指标 ,其表达水平的变化可为临床判断患者疗效。
Objective:To as s ess clinical significance of expression of peripheral blood CD44 in lymphocyte w ith lung cancer.Methods:Peripheral blood CD44 contents in 66 elderly patients with lung cancer were detected by the method of immune flow cytometry,28 normal donors and 35 patients with chronic bronchitis served as controls.Results:CD44 contents have di fferent expression in three groups.Perip heral blood CD44 in lymphocyte with lung cancer(583.52±18.64)were significantly higher than those in chronic bronchitis( 442.63±15.32, P <0.01)and normal control s(428.37±14.25, P <0.01);There are no di stinct difference between CD44 in chronic bronchitis and normal controls( P >0.05 ).CD44 in lymphocyte with pre operation or pre chemotherapy was significantly hi gher than those in after operation or ch emotherapy( P <0.01 or P <0.05).The exp ression of CD44 was not related to patho logical typing ( P >0.05),but closely as sociated with clinical staging and histo pathological grading ( P <0.01 or P <0. 05).Conclusion:Peripheral blood C D44 contents in lymphocyte with elderly lung cancer might be used as a marker of diagnosis;The change of its expression will provide a clinical proof to judge t he curative effect and prognosis.
出处
《临床肿瘤学杂志》
CAS
2003年第1期42-44,共3页
Chinese Clinical Oncology
关键词
抗原CD44
流式细胞术
肺肿瘤
外周血
Antigen
CD44 p rotein
Flow cytometry
Lung neoplasms
Peripheral blood
