摘要
目的:研究血浆同型半胱氨酸(Hcy)与缺血性脑血管病的关系,以及Hcy对其严重程度的影响。方法:采用荧光偏振免疫分析方法测定55例缺血性脑血管病患者和34例健康者血浆Hcy水平,同时记录入院时神经功能缺损评分(NIHSS评分),脑血管病组测量血压、血糖、Hcy并进行多元线性回归分析,分析它们之间的关系。结果:①病例组与对照组的血浆Hcy水平差异有显著性意义(t=3.018,P<0.01),病例组(16.76±14.77)μmol/L高于对照组(10.49±3.43)μmol/L。②脑血管病组中伴有高血压、糖尿病者和正常者的血浆Hcy水平差异无显著性意义。③脑血管病组中高Hcy血症者和正常Hcy者的入院评分差异有显著性意义;伴有高血压、糖尿病者和血压、血糖正常者的入院评分差异无显著性意义。④脑血管病组做血压、血糖、Hcy多元线性回归分析时,Hcy与脑卒中入院评分存在线性关系。结论:高同型半胱氨酸血症与缺血性脑血管病的危险性增加有关,并且增加其严重程度。
AIM:To study the relationship between plasma homocysteine(Hcy) and ischemic cerebrovascular diseases and the effect of Hcy on the severity of the disease. METHODS:Plasma Hcy levels of 55 cases with ischemic cerebrovascular diseases and 34 healthy subjects were measured by using immuno fluorescence polarization.Meanwhile,the evaluation of their neurological impairments were recorded and the blood pressure and blood sugar of patients in the case group were measured when they were hospitalized,which was followed by multiple linear regression analysis on blood pressure,blood sugar and plasma Hcy level. RESULTS: ①Plasma Hcy level in the patients[(16.76±14.77) μmol/L] was significantly higher than that in the controls[(10.49±3.43) μmol/L](t=3.018,P< 0.01).②There was no siguificant difference among the patients with hypertension,the patients with diabetes and normal subjects in the level of plasma Hcy.③There was a significant difference between the evaluation score for the patients with hyperhomocysteinemia and that for the normal ones in the case group at admission,but no significant difference was observed between hypertensive or diabetic patients and patients with normal pressure and blood sugar.④Multiple linear regression analysis in the cases showed that when blood pressure,blood sugar and Hcy were considered,linear relationship could only be found between Hcy level and hospitalization grade of stroke. CONCLUSION:Hyperhomocysteinemia is related with the risk for ischemic cerebrovascular diseases and its severity.
出处
《中国临床康复》
CAS
CSCD
2004年第10期1882-1883,共2页
Chinese Journal of Clinical Rehabilitation
基金
黑龙江省科技攻关计划项目资助(GB02C137-03)~~
