摘要
目的 :了解西北地区脑梗死和冠心病等心脑血管疾病患者血清同型半胱氨酸 (homocysteine,Hcy)、血脂水平的关系 .方法 :采用荧光偏振免疫分析方法 ,对 34例脑梗死患者 ,5 8例冠心病患者及 1 2 2例健康人进行血清Hcy的检测 ,同时测定其血脂水平 .结果 :脑梗死患者血清Hcy水平为(30 .5± 1 5 .4 ) μmol·L-1 ,冠心病患者血清Hcy水平为 (2 5 .5±1 3.5 ) μmol·L-1 ,与正常对照 (1 4 .2± 6 .9) μmol·L-1 比较 ,具有显著性差异 (P <0 .0 1 ) .脑梗死和冠心病患者血清Hcy水平与血脂无明显相关 (P >0 .0 5 ) .结论 :高Hcy血症是脑梗死、冠心病等心脑血管疾病独立的致病因素 。
AIM: To investigate the alterations of serum homocysteine (Hcy) levels in cerebral infarction and coronary heart disease (CHD) in the northwest region and to evaluate the relationship between the serum Hcy levels and lipid levels. METHODS: Serum Hcy levels of 34 patients with cerebral infarction and 58 patients with CHD and 122 normal controls were measured by using fluorescence polarization immunoassay (FPIA) technology and their serum lipid levels examined by automatic biochemistry analyzer. RESULTS: The mean serum Hcy level was (30.5±15.4) μmol·L -1 for cerebral infarction patients, (25.5±13.5) μmol·L -1 for CHD, and (14.2±6.9) μmol·L -1 for normal subjects. Statistically, the mean serum Hcy levels of cerebral infarction and CHD patients were significantly higher than those of the normal subjects ( P <0.01). No significant correlation was found between the serum Hcy and serum lipid in cerebral infarction patients and CHD patients ( P > 0.05 ). CONCLUSION: Hyperhomocysteinaemia is an independent risk factor for cerebral infarction and CHD.
出处
《第四军医大学学报》
北大核心
2003年第23期2157-2158,共2页
Journal of the Fourth Military Medical University
关键词
同型半胱氨酸
血脂
脑梗死
冠心病
荧光偏振免疫分析
homocysteine
serum lipid
cerebral infarction
coronary heart disease
fluorescence polarization immunoassay
