摘要
目的 探讨血清一氧化氮 (NO)和血浆内皮素 1(ET 1)对先天性心脏病 (CHD)患儿肺动脉高压 (PH)形成的影响。方法 选择健康儿童 3 0例为对照组 (A组 ) ;3 0例肺动脉压正常的CHD患儿为B组 ;3 0例CHD并PH患儿为C组。采用硝酸还原法对其血清NO+ 2 /NO+ 3 、放免法对其血浆ET 1浓度进行测定。结果 B组血清NO+ 2 /NO+ 3 浓度较A组明显增高 ;C组血清NO+ 2 /NO+ 3 浓度较A组低 ;无论是否并PH ,A、B两组与对照组相比 ,其血浆ET 1浓度均增高。结论 血清NO+ 2 /NO+ 3 浓度和血浆ET
Objective To explore the effects of serum nitrous ox ide(NO) and plasma endothelin(ET-1) on pulmonary hypertension in congenital he art disease (CHD)children.Methods Thirty healthy children were randomly selected as control group(A group), another 30 children with CHD and normal pulmonary arterial pressure(PAP) as B group, and the other 30 children w ith CHD and pulmonary hypertension(PH) were in the experimental group as C gr oup.The concentrations of serum NO and plasma ET-1 in each group were measure d with nitric acid-restored method and radioactive-immunization method. Results Serum NO + 2/NO + 3 in B group was higher than that of A group. Serum NO + 2/NO + 3 in C group was lower than that of A group. Plasm a ET-1, with or without PH, children's plasma ET-1 was higher than that of A group.Conclusion The concentration of serum NO + 2/NO + 3 a nd plasma ET-1 and the balance relationship between them may affect the format ion and the extent of PH.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第3期193-194,共2页
Journal of Applied Clinical Pediatrics
