摘要
目的研究先天性心脏病(CHD)患儿血浆硫化氢(H2S)含量与正常小儿有何差异,并探讨其病理生理学意义。方法先天性心脏病和对照组各9例,测定其心率、血压、肺动脉压及血浆H2S含量,分析CHD患儿与对照组血浆H2S含量的差异及其与肺动脉压力的关系。结果CHD患儿血浆H2S含量为(32.13±2.25)μmol/L,低于对照组的(43.69±2.05)μmol/L,差异有显著性(P<0.01)。血浆H2S含量与肺动脉压力呈明显负相关(r=-0.864P<0.05)。结论内源性H2S的下调可能在CHD继发肺动脉高压的发病过程中起重要作用。
Objective To investigate the changes of hydrogen sulfide (H_2S) level in plasma in order to explore the role of H_2S in the development of pulmonary hypertension (PH) secondary to congenital heart disease (CHD).Methods There were 9 CHD patients and 9 normal children in this study. The plasma concentration of H_2S and pulmonary artery pressure (PAP) of each child were measured. Meanwhile, the relationship between H_2S level and PAP was analyzed.Results The plasma level of H_2S in the group of CHD significantly decreased compared with control group (32.13±2.25) μmol/L vs [(43.69±2.05)μmol/L, P <0.01]and a negative correlation existed between plasma H_2S concentration and PAP ( r =-0.864 P <0.05).Conclusion Endogenous H_2S might play an important role in the development of PH secondary to CHD.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第7期632-634,共3页
Journal of Applied Clinical Pediatrics
基金
国家杰出青年科学基金项目资助(30425010)
国家重点基础研究发展规划项目资助(G2000056905)
关键词
硫化氢
心脏病
先天性
肺动脉高压
hydrogen sulfide
congenital heart disease
pulmonary hypertension
