摘要
目的 探讨脑缺血再灌流损伤中一氧化氮与自由基所起的作用及二者间的相互关系。方法 通过暂时夹闭大鼠两侧颈总动脉 ,造成大鼠脑缺血再灌流模型。取各组大鼠海马组织 ,测定其一氧化氮和丙二醛的含量 ,观察二者在脑缺血再灌流不同时间的动态变化。结果 脑缺血再灌流组大鼠与假手术组相比 :大鼠海马组织中一氧化氮含量明显升高 (P <0 0 1) ,其中在灌流 6h时的一氧化氮含量最高 ;大鼠海马组织中丙二醛含量也显著升高 (P <0 0 1)。结论 在急性脑缺血再灌流损伤过程中 ,一氧化氮既具有保护作用又具有细胞毒性作用。它主要通过介导自由基的大量产生 。
Objective To investigate the effect and relations of the nitric oxide and the free radical during the cerebral ischemic reperfusive injury in rats.Methods The model of the rats cerebral ischemia-reperfusion was made by the transient occlusion of the rats bilateral carotid arteries.To observe the dynamic change of NO and MDA content in the rats hippocampus during the cerebral ischemic reperfusive injury.Results The cerebral ischemia-reperfusion group compared with the control group:NO and MDA content of the rats hippocampus increased significantly(P<0 01).At the reperfusion 6h, NO content reach its climax.Conclusion NO is possessed the protective and cell-toxic effect,it outputs the cell-toxic effect by deducing the produce the free radical.
出处
《河南实用神经疾病杂志》
2004年第2期1-2,共2页
Henan Journal of Practical Nervous Diseases
