摘要
为了研究补充FDP对递增运动负荷训练至力竭的运动性疲劳大鼠在运动与恢复期间疲劳的产生、积累和清除这一渐进的、连续的过程中,心肌与血清中SOD、MDA、LDH和CK的影响及其变化规律。以SD大鼠为研究对象,测定运动训练5周、力竭后即刻、力竭后6h、力竭后24h心肌和血清中LDH、CK、SOD活性和MDA水平,安静对照组(UT)则测定其安静状态下上述相同的实验指标。结果发现:1)中小强度运动训练5周后,FDP组(TT)心肌和血清中各指标与运动对照组(TC)相比均没有显著性差异;2)力竭后即刻及恢复各时相FDP组心肌CK和LDH活性均显著性高于对照组;而血清中却显著性低于运动对照组;3)力竭即刻及恢复各时相,FDP组心肌与血清中SOD活性和SOD/MDA的比值均显著性高于运动对照组,MDA含量显著性低于运动对照组。表明:FDP均能提高运动力竭后即刻及力竭后恢复各时相心肌和血清中SOD的活性和SOD/MDA的比值,抑制MDA的生成;改善心肌内CK和LDH活性,降低血清内CK和LDH活性;说明FDP能促进心肌组织糖酵解,改善心肌的能量供应,提高抗脂质过氧化,加速疲劳的消除,对心肌细胞具有良好的保护作用。
This research explores the effects of fructose-1,6 -diphosphate （FDP） on superoxide dismutase （ SOD）, lactate dehydrogenase（LDH）, creatine kinase（CK） enzymes and malondialdehyde（MDA） of myocardium and serum in exerciseinduced fatigue rats which were exhausted by increasing exercise load. This research adopted SD rats as the research subjects. SOD,MDA,LDH and CK of both myocardium and serum were measured 5-weeks later, immediately after exhaustion, 6 hours and 24 hours after exhaustion. The same parameters were also measured in the untrained group （UT）. The results indicate that ： （ 1 ） After 5-week incremental exercise from low to medium intensity, SOD, MDA, LDH and CK of both myocardial and serum were not significantly different between FDP-treated trained group （TT）and trained control group （TC） ; （2） Right after exhaustion and all the time phases, myocardial CK and LDH reached their peaks in TT, which were significantly higher than those in TC. While serous LDH and CK increased remarkably in Tr, which was much lower than that in TC. （3） Right after exhaustion and each time phase, myocardial and serum SOD and SOD/MDA ratio in TT were significantly higher than those in TC, while MDA was significantly lower than that in TC. It might be concluded that FDP could promote myocardial and serum SOD and SOD/MDA ratio immediately after exhaustive exercise,recovery phase, prohibit the product of MDA, improve myocardial CK and LDH, decrease the generation of serum CK and LDH. FDP could accelerate glycolysis process of myocardium tissue .ameliorate energy supply, improve the resistance to lipid peroxidation and facilitate the removal of fatigue, So FDP could be considered as a better protectors of myocardium cell membrance.
出处
《北京体育大学学报》
CSSCI
北大核心
2005年第8期1082-1085,共4页
Journal of Beijing Sport University
