摘要
脑缺血再灌注过程中,脑组织一氧化氮(NO)含量呈"双峰样"变化。作用也随其在机体内含量变化具有不同表现;NO主要通过4条信号通路影响细胞凋亡。NO可通过分子修饰使相关蛋白发生S-亚硝基化,调节信号通路,进而影响细胞凋亡。
Nitric oxide level in cerebral tissue show a ＂double peaks-like＂profile during cerebral ischemia-reperfusion,and the function of nitric oxide will change depending on its level in vivo. Nitric oxide mediated apoptosis mainly through four signal pathways. Nitric oxide can make related protein S-nitrosylation via molecular modification,further regulate signal pathways and affect apoptosis.
出处
《基础医学与临床》
CSCD
2015年第3期413-416,共4页
Basic and Clinical Medicine
基金
首都医科大学基础临床课题(12JL41
13JL77
14JL01)
首都医科大学科研基金课题(2013ZR05)
