摘要
目的:考察氟比洛芬巴布剂与对照混悬剂在人体内的药代动力学。方法:8名健康志愿者自身交叉口服混悬剂100mg或外贴巴布剂600mg,采用高效液相色谱（HPLC）法测定血浆中氟比洛芬浓度。结果:氟比洛芬混悬剂和巴布剂的t1/2分别为5.91和7.7h,MRT分别为5.93和19.4h,经单侧t检验均有显著差异（P<0.05）。结论:氟比洛芬巴布剂可以明显减少血药浓度波动,延长作用时间。
Aim: To study the pharmacokinetics of flurbiprofen cataplasms and suspensions in healthy volunteers. Methods: A single oral dose of 100 mg flurbiprofen suspension or transdermal dose of 600 mg cataplasm was given to 8 male subjects in a randomized crossover study. The plasma concentrations of flurbiprofen were determined by HPLC method. Results: t1\2 of suspensions and cataplasms of flurbiprofen were 5. 91 and 7. 7 h, MRT were 5. 93 and 19. 4 h. There was significant difference in t1\2 and MRT between two preparations (F<0. 05). Conclusion: Flurbiprofen cataplasms may reduce the fluctuation of plasma leval, and prolong the time of action.
出处
《药学服务与研究》
CAS
CSCD
2001年第1期22-24,共3页
Pharmaceutical Care and Research
