摘要
在5～40mg/kg剂量范围内,液化石油气(LPG)燃烧颗粒物的提取物对大鼠肺 AHH和GST具有明显的诱导作用,其中对肺AHH的诱导大大超过对GST的诱导。当总染毒剂量相同时,少量多次诱导的酶活性高于一次大剂量诱导的酶活性。各剂量组肝AHH和GST活性与对照组相比未见明显变化。结果提示,LPG燃烧颗粒物进入肺脏后可诱导并改变其有关代谢酶的代谢模式,从而加速PAH和NO_2-PAH等致癌物质在肺内的代谢活化。
The research to evaluate the effect of the extracts of the particulates upon the activities of AHH and GST of lung and liver in rats was conducted. The extracts were given to the rats by intratracheal instillation at 5, 10, 20, 40mg/kg once (single treatment), and 5 mg/kg once a day for 4 consecutive days ( multiple treatments ). The results showed that the extracts induced the activities of AHH and GST in the lung. The high magnititude induction was obtained in the rats received multiple treatments.The altered metabolic model could obviously favour to the formation of adverse intermediates of PAH and NO2-PAH, which might enhance the vulnerability to lung cancer.
出处
《卫生毒理学杂志》
CSCD
1992年第1期21-23,共3页
Journal of Health Toxicology
基金
国家自然科学基金
关键词
液化石油气
颗粒物
芳香烃羟化酶
LPG
Particulate
Aryl hydrocarbon hydroxylase GSH S-transferase
