摘要
应用ＴＡ９８及其衍生物，检测了沈阳市不同功能分区大气悬浮颗粒提取物的致突变性，并对各菌株进行了比较。结果显示，在无Ｓ９存在时，颗粒提取物对菌株ＹＧ１０２４、ＹＧ１０２１及ＴＡ９８的直接致突变作用高于菌株ＴＡ９８ＮＲ、ＴＡ９８／１，８ＤＮＰ６，并以ＹＧ１０２４升高最明显。提示颗粒提取物含有ＮＯ２－ＰＡＨｓ，其中硝基芘类，特别是二硝基芘类是该颗粒物中主要直接致突变物。ＹＧ菌株，特别是ＹＧ１０２４在检测含有ＮＯ２－ＰＡＨｓ的环境样本中的致突变性更为敏感。实验结果提示沈阳市工业区、居民区污染严重。
The mutagenicity of airborne particulates from differential function districts in Shenyang was studied with salmonella typhimurium strain TA98, the classically beliered sensitive strain, and its new derivative strains TA98NR, TA98/1 ,8DNP6, YG 1021 and YG1024,and sensitivity of these new strains were compared with that of TA98. The results indicated that the mutagenicity of samples for YG1024,YG1021 and TA98 were significantly stronger than that for TA98NR and TA98/1, 8DNP_6. Strain YG1024 was more specific to the mutagenicity of samples than TA98. This strongly suggests the presence of nitrated polycyclic aromatic hydro-carbons (NO2-PAHs)in these particulates and that nitropyrenes must be the major direct-acting mutagens, especically dinitropyrenes (DNPs) . YG1024 can become the ralatively sensitive indicating strain in detecting mutagenicity of samples of environment. The results indicated samples from industrial and residential districts contained more NO_2-PAHs than that from other districts.
出处
《首都医科大学学报》
CAS
1996年第4期263-266,共4页
Journal of Capital Medical University
关键词
大气颗粒物
致突变性
TA98
airborne particulate
mutagenicity
Ames test
nitrated polycyclic aromatic hydrocarbons ( NO2-PAHs)
