摘要
本文首次采用TA98的缺乏硝基还原酶的衍生菌株TA98NR和TA98/1,8-DNP_6对北京市家用液化石油气燃烧颗粒物进行了致突变活性研究。结果显示,该颗粒物的二氯甲烷提取物对TA98、TA-98NR、TA98/1,8-DNP_6均具有明显的直接和间接致突变作用,但对TA98NR和TA98/1,8DNP_6的直接回变数比其母株TA98分别降低42％和54％。表明该颗粒物中含有直接致突变的硝基多环芳烃,其中硝基芘类特别是二硝基芘类是该颗粒物中主要的直接致突变物质。这些致突变/致癌物的存在,可能与室内污染造成家庭主妇的肺癌高发有关。
Liquefied petroleum gas ( LPG ) has been widely used for cooking at home by urban residents in China since 1965, and its incomplete combustion products also are cited as direct-acting mutagens and may be carcinogens. The mutagenicity of the paniculates produced by LPG combustion in Beijing was studied with Salmonella typhimurium strain TA98 and its nitroreductase-deficient derivatives TA98NR and TA98/1, 8-DNP6. Methylene chloride extracts of the particulates showed mutagenicity for the three strains with or without S9 mix. The reve-rtants of the extracts in strains TA98NR and TA98/1, 8 -DNP6 were less than 40% and 50% of that in the parent strain TA98, respectively. This observation strongly suggests the presence of nitrated polycyclic aromatic hydrocarbons (NO2-PAHs)in those particulates and that ni-tropyrenes must be the major direct-acting mutagens, especially dinitropyrenes. The presence of these mutagenic / carcinogenic agents in indoor pollutants may be related to the high incidence rate of housewife lung cancer.
出处
《环境与健康杂志》
CAS
CSSCI
CSCD
北大核心
1990年第2期49-53,共5页
Journal of Environment and Health
