摘要
目的 :研究双相情感障碍联合治疗的进展 ,评价其疗效与安全性 ,以期为临床合理应用提供参考。方法 :查阅近期相关国内、外文献 ,对涉及各临床时期的双相情感障碍联合治疗研究进展和临床评价进行介绍。结果与结论 :目前的研究结果提示 ,对于急性躁狂患者 ,非典型抗精神病药与心境稳定剂联用可明显提高疗效 ,且起效更迅速。对于双相抑郁患者 ,在心境稳定剂的基础上 ,加用帕罗西汀等新型抗抑郁药可改善疗效 ,且不增加转相的风险 ;关于维持治疗中的联合用药问题 ,锂盐和三环类抗抑郁药(TCA)长期联用并无优越性 ,且TCA会诱发躁狂。而心境稳定剂与新型抗抑郁药联用的长期随机对照研究仍很缺乏 。
OBJECTIVE: To research on progress of combined therapy of bipolar psych osis and evaluate the efficiency and safety in order to supply references for ra tional usage in the clinic . METHODS: By reviewing recent literatures at home an d abroad introducing combined therapeutic progress and clinical evaluation of bi polar psychosis in different clinical stage . RESULTS & CONCLUSION: This result shows that a typical psychotolytic combined with mood stabilizer can obvi ously increase the efficiency and go into effect quickly for acute maniac .For t he patients with bipolar depression , adding some new type of antidepressant suc h as Paroxetine in addition to mood stabilizer could improve the efficie ncy without increasing phase inversion risk ; with respect to maintaining combin ed drug usage in the therapy , long-term combined usage of Lithium and TCA has n o precendence ,TCA may induce mania .Up to now ,there still lacks of long-term f ollow-up control study of mood stabilizer combined with new type of antidepressa nt , so their efficiency and safety should be done more study and observation.
出处
《中国医院用药评价与分析》
2003年第5期271-274,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
