摘要
目的 :比较利培酮和氯氮平分别合并碳酸锂治疗急性躁狂的疗效和安全性。 方法 :将符合 CCMD- 2 - R诊断标准的 6 8例各型急性躁狂患者 ,随机分为两组 ,在使用碳酸锂的基础上分别联合利培酮或氯氮平进行为期 8周的治疗。 结果 :利培酮组在治疗第 2、4、8周周末显效率分别为 18.8%、71.9%和 87.5 % ,有效率为 6 8.8%、87.5 %、93.8% ,与氯氮平组相似 ;但前者第 1周周末有效率(2 8.1% )不及后者 (5 5 .6 % )。 结论 :利培酮合并碳酸锂治疗急性躁狂具有与氯氮平合并碳酸锂相似的总体疗效、更高的安全性 ,但起效稍迟 ,可作为急性躁狂治疗的一个选择。
Objective:To compare the efficacy and safety of risperidone or clozapine both combined with lithium in acute mania. Method:Sixty eight patients with acute mania (CCMD 2 R) were randomly assigned to receive risperidone or clozapine both combined with lithium for 8 weeks.Treatment efficacy and safety were evaluated with Bech Rafaelsen mania rating scale (BRMS) and treatment emergent symptom scale (TESS) separately. Results:In both groups,total score on BRMS was significantly reduced from baseline,with no significant difference between groups.On the basis of the clinical response criteria (reduction of 30% or more in total BRMS score),more clozapine treated patients (55 6%) responded significantly than those assigned to risperidone (28 1%) at the first weekend But the study failed to find any significant differences between the two groups after 2,4 and 8 weeks. Conclusion:Risperidone combined with lithium was well tolerated and as effective as clozapine plus lithium in acute mania.When antipsychotic is necessary to acute mania,risperidone may be a consideration.
出处
《临床精神医学杂志》
2001年第6期337-339,共3页
Journal of Clinical Psychiatry
关键词
躁狂
利培酮
氯氮平
碳酸锂
治疗
Mania
Risperidone
Clozapine
Lithium carbonate
