摘要
目的 观察中草药益母草对醋酸铅引起的小鼠雄性生殖细胞遗传损伤作用。方法 采用小鼠精子畸形试验、精原细胞姐妹染色单体互换试验和小鼠精子非程序DNA合成试验。结果 在 2 0～ 8 0g kg剂量范围 ,益母草对醋酸铅所诱发的小鼠精子畸形、精原细胞姐妹染色单体互换和小鼠精子非程序DNA合成有明显的抑制作用 (P <0 0 1) ,并且随着益母草浓度的增加 ,其抑制作用逐渐增强。
Objective To observe the preventive effect of herba leonuri on damage of genetic materials in male mouse reproductive cells induced by lead acetate(Pb(CH 3COO) 2). Methods Sperm abnormality test,sister chromatid exchange (SCE)in mouse spermatogonia and unscheduled DNA synthesis (UDS) test in male mouse reproductive cells were used in the study.Results Herba leonuri in dose ranged from 2.0 g/kg to 8.0 g/kg,inhibited strikingly sperm abnormality,SCE in mouse spermatogonia and UDS in mouse sperm induced by Pb(CH 3COO) 2 (P<0.01),and the inhibitory effect was enhanced with the incresse of the concentration.Conclusion Herba leonuri shows a protective effect,namely antimutagenesis,on injury of genetic materials in reproductive cells of male mouse.
出处
《卫生毒理学杂志》
CAS
CSCD
北大核心
2003年第4期211-213,共3页
Journal of Health Toxicology
基金
吉林省自然科学基金资助课题 (2 0 0 1 0 52 9)
