摘要
本文采用小鼠精原细胞姐妹染色单体互换（ＳＣＥ）实验方法，研究了人参茎叶总皂甙（ＧＮＳ）对丝裂霉素Ｃ（ＭＭＣ）引起的小鼠精原细胞遗传物质损伤的影响。结果表明，ＧＮＳ不能诱发小鼠精原细胞ＳＣＥ，而且在腹腔注射ＭＭＣ的同时给予ＧＮＳ，可使ＭＭＣ诱发的小鼠精原细胞ＳＣＥ频率明显降低。为此，我们认为ＧＮＳ对小鼠生殖细胞遗传物质具有保护作用。
with sister chromatid exchange(SCE) test,
influences of ginsenosides from stemand leaves(GNS)on damage of genetic materials induced
by mitomycin C(MMC)in mousespermatogonia were studied. the results showed that GNS could
not induce SCE in mouse sper-matogonia, but the frequencies of SCE induced by MMC in
mouse spermatogonia were reducedsignificantly if GNS and MMC were given ip
simultaneously。 Thus, we consider that GNS has aprotective effect on genetic materials in
genital cells
出处
《白求恩医科大学学报》
CSCD
1994年第3期227-229,共3页
Journal of Norman Bethune University of Medical Science
关键词
人参
皂甙
药理
丝裂霉素
Ginseng
Saponins/PD
mitomycins/PD
sister chromatid exchange/DE
sper- matogonia/DE
