摘要
目的:考察大剂量益母草对大鼠肝、肾的亚急性毒性影响。方法:取益母草煎液,以60g·kg^(-1)·d^(-1)剂量灌胃给予大鼠,每日1次,连续给药15d,停药后继续观察15d。实验第15天、第30天时取大鼠血和肝、肾组织标本,分别检测相关肝、肾功能指标,并观察肝、肾形态组织学变化。结果:给药15d后,大鼠血清谷氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平,N-乙酰氨基葡萄糖苷酶(NAG)活性,及尿素氮(BUN)、肌酐(cr)和尿蛋白(Upro)水平均明显升高,与空白对照组相比差异有统计学意义,肝、肾组织可见轻度病理改变。停药15d后,给药组大鼠尿蛋白水平未见降低,其余各项指标水平均降低,肝、肾组织病理改变减轻。结论:大剂量益母草对大鼠肝、肾有毒性作用,其毒性影响在短期内不完全可逆。
Objective： To study the subacute toxic effects of Herba Leonuri on the liver and kidney in rats. Method： Herba Leonuri decoction was administered intragastrically to rats consecutively at the dose of 60g· kg^-1 · d^-1 for 15 days. Rats were continued fed without treatment for the following 15 days. At the fifteenth day and the thirtieth day, the liver and renal functions were measured and the pathological examinations of the tissues were performed. Result： There were significant difference in the activities of ALT, AST and NAG, and the levels of BUN, Cr and Upro in serum served as marks of liver and renal functions between rats treated with Herba Leonuri and normal rats. Herba Leonuri caused lighter pathological injury to the liver and kidney. After recovery for 15 days, the levels of the biochemical parameters except for Upro in treated rats decreased, and the degree of injury to the tissues lessened. Conclusion： Herba Leonuri displayed toxic effects on liver and renal in rats at high dose. The toxic effects were partly reversible in short time.
出处
《中国药师》
CAS
2009年第9期1180-1182,共3页
China Pharmacist
关键词
益母草
肝
肾
毒性
大剂量
Herba leonuri
Liver
Kidney
Toxicity
High dose
