摘要
目的 探讨早期营养干预对宫内生长迟缓 (IUGR)幼鼠血清胰岛素样生长因子 (IGF)和小肠发育及生长追赶的影响。方法 将 2 4只IUGR新生雌鼠和 8只正常新生雌鼠随机分为 4组 :IUGR模型组 ,IUGR低蛋白组 ,IUGR高蛋白组 ,正常对照组。于生后 4周时检测各组大鼠血清IGF1、胰岛素样生长因子结合蛋白 3(IGFBP3)浓度、体重、身长和小肠重量、长度及肠黏膜组织结构变化。结果 4周时IUGR高蛋白组血IGF1、IGFBP3和小肠黏膜绒毛高度、吸收表面积均显著高于对照组和IUGR模型组 (P <0 .0 5或P <0 .0 1) ;小肠重量、长度和体重、身长与对照组比较无显著性差异 (P均 >0 .0 5 )。结论 生后头 4周予高蛋白饮食早期营养干预IUGR幼鼠 ,可通过促进小肠发育达到满意的体格生长追赶。
Objective To study the effect of early nutritional intervention on the serum insulin-like growth factors(IGF1),insulin-like growth factor binding protein 3(IGFBP3), intestinal development and catch-up growth in rats born with intrauterine growth retardation(IUGR).Methods Twenty-four IUGR female rats and 8 normal female rats were divided randomly into 4 groups: 1.IUGR control,2.IUGR low-protein diet group,3.IUGR high-protein diet group,4.normal control group.At 4th week of life,the serum IGF1,IGFBP3, body weight,length, and intestinal weight, length, intestinal constitution were measured in all groups.Results At the 4th week, the serum IGF1, IGFBP3, intestinal villi height and villi absorbing area in IUGR high-protein diet group were significantly higher than those in normal control group and IUGR control group( P<0.05 or P<0.01). The intestinal weight, length and body weight,length were not significantly different compared with normal control group(P>0.05).Conclusions The high-protein diet of early nutritional intervention during 4th week of life is helpful for catch-up growth by promoting the intestinal development in rats born with IUGR. The serum IGF1 is a sensitive index to the catch-up growth.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第12期949-951,共3页
Journal of Applied Clinical Pediatrics
基金
广东省重点科技基金资助项目 (项目编号 :99M0 4 81 5G)
关键词
宫内生长迟缓
大鼠
营养干预
胰岛素样生长因子
小肠发育
生长追赶
intrauterine growth retardation
rat
nutritional intervention
insulin-like growth factors
intestinal development
catch-up growth
