摘要
在pH1.4～2.4的NaAc HCl酸性缓冲介质中,药物雷洛昔芬与依文思蓝作用,形成离子缔合物,在280nm处产生强吸收。在此波长处吸光度A与雷洛昔芬浓度在0～2.3×10-5mol·L-1范围内,遵守比耳定律。建立了测定雷洛昔芬的分光光度法,测得表观摩尔吸光系数ε280达1.84×104L·mol-1·cm-1。该方法操作简便快捷,灵敏度较高,体系稳定。用于合成样中雷洛昔芬的测定,结果满意。
In sodium acetate-hydrochloric acid buffer solution at pH 1.4～2.4,Raloxifene reacts with Evans blue and forms an ion-association complex. The maximum absorbance wavelength is at 280 nm.Raloxifene abides by Beer law in the range of 0～2.3×10^(-5)mol·L^(-1). The apparent molar absorptivity ε_(280) is 1.84×10^(4)L·mol^(-1)·cm^(-1).The method has easy operation high sensitivity and fairly good selectivity .It has been applied to the direct determination of Raloxifene in the synthetic samples with satisfactory results.
出处
《重庆师范大学学报（自然科学版）》
CAS
2003年第4期43-45,共3页
Journal of Chongqing Normal University:Natural Science
