摘要
目的 探讨CD54在肾细胞癌外周血淋巴细胞中的表达及临床意义。方法 应用流式细胞免疫学方法检测30例肾细胞癌外周血淋巴细胞中CD54的表达,并与肾良性病变组(20例)和正常对照组(20例)进行对照。结果 肾细胞癌30例外周血淋巴细胞中CD54的表达均明显高于肾良性病变组和正常对照组(231±10:218±7,231±10:218±1;P<0.01),肾良性病变组和正常对照组之间CD54的表达,差异无显著性(218±7:218±1,P>0.05)。T3+T4期和T1+T2期之间CD54的表达比较,差异呈显著性(235±10:226±9,P<0.05)。肾癌伴淋巴结转移CD54的表达均高于不伴淋巴结转移,差异呈显著性改变(236±10:227±9,P<0.05)。肾癌不同组织类型的CD54的含量差异无显著性(231±1:231±8,231±1:226±1,231±8:226±1;P>0.05)。结论 肾细胞癌外周血淋巴细胞中CD54的检测对肾肿瘤性质鉴别、肾癌浸润转移和预后的估计有重要临床价值。
AIM To investigate the expression of peripheral blood CD54 and its clinical implication in primary renal cell carcinoma(RCC). METHODS Peripheral blood CD54 contents in 30 patient with RCC were detected by flow-cytometry, and 20 patient with benign lesion and 20 normal donors served as controls. RESULTS The CD54 contents in peripheral blood lymphocyte with RCC were significantly higher than those in benign lesion and normal controls (231±10:218±7, 231±10:218± 1;P<0.01). There is no distinct difference between CD54 in benign lesion and normal controls(218±7:218±l,P>0.05). CD54 content in stage T3,T4 was higher than that in stage T1,T2. RCC with lymph node metastasis or distance metastasis had higher expression of CD54 than RCC without lymph metastasis or distance metastasis(235±10:226±9,P<0.05;236±10:227±9,P<0.05). No difference in CD54 contents was observed between different histopathological types of RCC(231±1: 231±8,231±1:226±1,231±8: 226±1;P>0.05).CONCLUSION The assessment of CD54 in RCC and benign lesion might be an important means to differentiate benign from malignant renal tumor; and to detect the invasive or metastasis and estimate prognosis of RCC.
出处
《现代泌尿外科杂志》
CAS
2003年第4期208-210,共3页
Journal of Modern Urology
