摘要
为探讨老年肺癌患者外周血淋巴细胞中ICAM 1的表达及化疗对其的影响 ,应用流式细胞术检测了 5 2例老年肺癌患者化疗前后外周血淋巴细胞中ICAM 1的含量 ,与 32例健康老人及 35例肺部良性疾患进行对比研究。结果发现 ,老年肺癌外周血ICAM 1的表达明显高于正常老人及肺部良性疾患 ;Ⅲ、Ⅳ期和Ⅰ、Ⅱ期肺癌患者之间ICAM 1的表达存在显著差异 ;且化疗后外周血中ICAM 1的表达水平明显低于化疗前。表明外周血ICAM
To investigate the expression of ICAM 1 in peripheral blood lymphocyte in elderly patients suffering from lung cancer and the effect of chemotherapy on the expression of ICAM 1, peripheral blood ICAM 1 contents in 52 elderly patients with lung cancer were assayed with the method of immune flow cytometry before and after chemotherapy, and 32 normal elders and 35 patients with benign disease in lung served as controls. The results showed that the expression of ICAM 1 on lymphocyte in elders with lung cancer was significantly higher than that in patients with benign disease and normal controls. There was a significant difference between ICAM 1 expression in patients in stage Ⅲ, Ⅳ and that in patients in stage Ⅰ and Ⅱ. ICAM 1 in peripheral blood before chemotherapy was significantly higher than that after chemotherapy. It is suggested that the expression of ICAM 1 in peripheral blood lymphocyte might be useful to judge the efficacy of chemotherapy and evaluate prognosis in geriatric patients with lung cancer.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第3期273-274,共2页
Medical Journal of Chinese People's Liberation Army
