摘要
目的观察河北地区汉族肾小球疾病患者骨密度 (bonemineraldensity ,BMD) ,并分析影响BMD的因素。方法采用双能X线骨密度仪 ,测定 2 0 8例肾功能正常的成年肾小球疾病患者用肾上腺皮质激素前腰椎(lumbarspine ,L1～ 4)和股骨BMD。结果本组患者BMD与北京地区接近 ,高于长沙地区健康女性。男性 30岁以后各部位BMD随年龄增加而逐渐下降 ,女性则于 5 0岁以后快速下降。大于 5 0岁组男、女患者BMD较峰值年龄组减少 (0 .10 6～ 0 .2 6 0 ) g/cm2 ,以股骨三角区最明显。各部位BMD与肾小球病理类型无关 ,与体质量 (r =0 .2 2 2～ 0 .4 2 9,P≤ 0 .0 0 1)和体质量指数 (r =0 .2 5 0～ 0 .314 ,P≤ 0 .0 0 1)呈显著正相关 ,L3 、股骨颈和三角区BMD与年龄 (r =- 0 .12 9～ - 0 .5 4 3,P≤ 0 .0 1)呈负相关关系。结论随增龄BMD逐渐减少 ,以股骨三角区最明显 ,男、女开始骨丢失的年龄和速率不同 ,体质量指数和年龄是影响BMD的主要因素。
ObjectiveTo investigate bone mineral density(BMD) in Hanzu patients with glomerular disease in Hebei area and to analyze influencing factors on the BMD.MethodsThe BMD was measured by dual-energy X-ray absorptiometry at Lumbar spine (L 1-4) and proximal femur in 208 patients aged above 20 years who had normal renal function before receiving glucorticoids. ResultsIn our series,the patients′BMD was at approximately same level with that of the leateu adults in Beijing area,and higher than that of health the female in Changsha region.The BMD was gradually reduced with the growth of ages in men above 30 years old ,but decreased rapidly in the women over 50 years of age.The BMD was lower by( 0.106～ 0.260)g/cm 2 than their highest in both of male and female patients over 50 years old ,bone loss of ward triangle was the severest in all sites.All BMD sites were positively correlated with body weight (r= 0.222～ 0.429,P≤ 0.001) and bone mass index(BMI) (r= 0.250～ 0.314, P≤ 0.001).BMD of the L 3 and femur neck and trochanter inversely correlated with age(r= 0.129～ -0.543,P≤ 0.01),but were not associated with glomerular pathologic forms. ConclusionThe BMD was gradully declined with aging.The ward triangle reduced the severest among all BMD sites. The bone loss rate and age are different in men and women.The body mass index and age are major factors that mainly deternines BMD.
出处
《河北医科大学学报》
CAS
2003年第6期341-344,共4页
Journal of Hebei Medical University
关键词
肾小球
肾疾病
骨密度
kidney glomerulus
kidney diseases
bone density
