摘要
目的探讨糖皮质激素对结核性脑膜炎患儿骨代谢的影响。方法选择初治结核性脑膜炎30例患儿,观察组予抗结核及糖皮质激素治疗;以同期住院的30例上呼吸道感染患儿作对照组。治疗前和治疗4周分别测定血清Ⅰ型前胶原羧基末端前肽(PICP)和尿脱氧吡啶啉(DPD)。结果结核性脑膜炎患儿激素治疗前血清PICP、尿DPD排泄率和对照组比较均无差异(P均>0.05);激素治疗4周后血清PICP(108.85±46.13)μg/L较治疗前(152.99±44.78)μg/L明显降低,差异有显著性(P<0.01):激素治疗4周后尿DPD的排泄率(28.93±9.27)nmol/L较治疗前(19.94±5.77)nmol/L明显增高,差异有显著性(P<0.01)。结论激素治疗4周即可引起结核性脑膜炎患儿骨形成减少和骨吸收增加。
Objective To study the influence of glucocorticoid on bone metalism in children with tubercular meningitis. Methods Thirty children with tubercular meningitis were assigned as study group treated with anti-tuberculosis drugs and ghtcocorticoid, and 30 children with respiratory, infection during the ,same period as control group. The serum carboxyteminal propeptide of type Ⅰ procollagen（PICP） level and urine deoxypyridinoline（DPD） level before and after 4 weeks of treatment were measured by radioimmunoassayand competitive enzyme-1 inked immunoassay, respectively. Results There were no difference in scrum PICP and urine DPD between glucocorticoid pretreatment and control group （all P〉0.05）. The serum PICP of tubercular meningitis children after 4 neeks mglucocortieoid therapy （108.85±46.13）μg/L was significantly lower than that in control group （ 154.38±47.98 ） μg/L and glucocorticoid-pretreatment （ 152.99±44.78 ）μg/L（P〈 0.01）. The urine DPD significantly increased after glucccorticoid treatment for 4 weeks （28.93±9.27）nmol/L than those in control group （18.11±4.87）nmol/L and glucocorticoid pretreatment （19.94±5.77）nmol/L （P〈0.01 ）. Conclusion Glucocurticoid treatment for 4 weeks can decreased bone formation and increased bone absorption in tubercular meningitis.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第8期790-791,共2页
Journal of Applied Clinical Pediatrics
关键词
糖皮质激素
Ⅰ型前胶原禾端前肽
脱氧啶啉
脑膜炎
结核性
glucocoriticoid
carboxyterminal propeptide of type Ⅰ procollagen
deoxypyridinoline
meningitis,tubercular
