摘要
目的通过检测特发性身材矮小(ISS)儿童血清骨碱性磷酸酶(BAP)及骨钙蛋白(OC)水平,探讨其成骨细胞的功能状况。方法ISS组36例及健康对照组儿童50例。ISS组分为青春期前组及青春期组。测各组儿童身高、体质量、体质量指数,采用CHN法评定左侧手、腕部骨化指标,计算骨龄。采用ELISA法测其血清BAP及OC水平。结果青春期前,ISS儿童血清BAP及OC水平为(79.90±25.96)U/Lvs(60.96±18.46)μg/L,健康对照组为(152.17±35.36)U/Lvs(76.16±28.03)μg/L;青春期,ISS儿童血清BAP及OC水平为(108.33±35.20)U/Lvs(63.82±24.81)μg/L,健康对照组为(156.30±35.29)U/Lvs(104.92±28.26)μg/L。青春期前及青春期ISS组血清BAP及OC水平均明显低于健康对照组,存在显著性差异(Pa<0.01)。结论ISS儿童以成骨细胞为中心环节的骨塑造和再造能力均较健康生长发育少年儿童差。
Objective To detect serum bone specific alkaline phosphatase （BAP） and osteocalcin （OC） in children with idiopathic short stature （ ISS）, and explore the status of osteoblast. Methods Thirty - six cases of ISS in this study were divided into two groups （ preaddescence group and adolescence group） ,50 healthy children as control group. The height, weight and body mass index in every group were measured. Left hand and wrist were measured with CHN way for bone age. Serum BAP and OC were measured by enzyme linked immunosorbont assay （ELISA）. Results BAP and OC in ISS group of preadolescence were（79.90 ±25.96） U/L, （60.96 ± 18.46） μg/L, and（152.17 ±35.36）U/L, （76.16 ± 28.03 ） μg/L in normal children. In the ISS group of adolescence BAP and OC were （ 108.33 ±35.20） U/L, （63.82 ± 24.81 ） μg/L, and （ 156.30 ± 35.29 ） U/L, （ 104.92 ± 28.26 ） μg/L in normal group. There was significant difference between ISS and control group in both age in the~ levels of BAP and OC （ Pa 〈 0.01 ）. Conclusion The ability of osteoblast in ISS is lower than that in normal children in the process of bone modeling and remodeling.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第8期597-598,共2页
Journal of Applied Clinical Pediatrics
关键词
身材矮小
特发性
骨碱性磷酸酶
骨钙蛋白
生长和发育
idiopathic short stature
bone specific alkaline phosphatase
osteocalcin
growth and development
