摘要
目的 调查中国长沙地区女性不同骨胳部位与年龄相关的骨密度 (BMD)、累积骨丢失和骨质疏松症 (OP)的患病率。方法 用DXAQDR45 0 0A型扇形束骨密度仪测量 1818例 15～ 96岁女性腰椎前后位 (AP)和仰卧侧位、髋部及前臂的BMD。结果 按每 5岁年龄分组分析的结果显示 ,不同骨胳部位的峰值BMD分别发生在 2 0～ 2 4岁至 40～ 44岁之间 ,其中髋部的大转子和Ward’s区最早 (2 0～ 2 4岁 ) ,前臂 1/ 3处最晚 (40～ 44岁 ) ;到≥ 80岁累积骨丢失率最多的部位是Ward’s区(- 6 6 .8% ) ,最少的部位为前臂 1/ 3处 (- 33.2 % ) ;至少有一个骨胳区域的BMD值达到OP标准的发生率是 :30～ 39岁为 (0 .5± 0 .5 ) % ,40～ 49岁为 (5 .0± 4.5 ) % ,5 0～ 5 9岁为 (2 0 .9± 11.7) % ,6 0～6 9岁为 (5 4.9± 2 1.1) % ,70～ 79岁为 (72 .4± 18.6 ) % ,≥ 80岁为 (85 .6± 12 .0 ) %。结论 不同骨胳部位峰值BMD发生的年龄、累积骨丢失率和OP患病率存在明显差别。测量部位不同 ,OP的患病率不同 ,随年龄增长的OP患病率也不同。腰椎侧位是早期诊断OP的最敏感部位。
Objective To investigate the age related bone mineral density (BMD), accumulated bone loss, and the prevalence of osteoporosis at different skeletal sites in women from Changsha region in China. Methods BMD at anteroposterior (AP) and supine lateral lumbar spine, hip, and forearm was measured by DXA QDR 4500A fan beam bone densitometer in 1818 women from 15 to 96 years of age. Results Data were analyzed in groups divided by an interval of every 5 years of age. The peak BMD occurred earliest in the 20～24 years of age at trochanter and Ward's, and latest in the 40～44 years of age at one third (1/3) site of the distal forearm. Compared with BMD, theaccumulatedbonelossrateswere highest at the Ward's (-66.8%) and lowest at the 1/3 site of the distal forearm (-33.2%)inover80yearsof age. The prevalences of osteoporosis at least at one site of these women were (0.5±0.5)% in 30～39 years of age, (5.0±4.5)% in 40～49 years of age, (20.9±11.7)% in 50～59 years of age, (54.9±21.1)% in 60～69 years of age, (72.4±18.6)% in 70～79 years of age and (85.6±12.0)% in over 80 years of age. Conclusion Significant differences of age of peak BMD, accumulated bone loss rates and osteoporosis incidence were found among various skeletal sites. The incidence of osteoporosis varied with different sites measured and with aging. The supine lateral lumbar spine is the most sensitive site for osteoporosis diagnosis, especially in the early stage.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2000年第4期203-207,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家九五攻关课题!( 96 90 6 0 5 0 5 )
