摘要
本文比较三苯氧胺(TMX)或炔诺酮(NET)配伍dl-15-甲基前列晾素F_(2α)(15-m-PGF_(2α))的抗早孕效果。共123例早孕妇女,分成四组,Ⅰ组:单纯用TMX;Ⅱ组:TMX合用15-m-PGF_(2α)海绵栓;Ⅲ组TMX合用15-m-PGF_(2α)注射剂;Ⅵ纽NET合用15-m-PGF_(2α)注射剂。抗早孕效果以Ⅳ组最佳,完全流产率达95%(与其它三组比较P<0.05),不全流产率3.3%,其余依次Ⅲ组完全流产率85%,不全流产率15%;Ⅱ组完全流产率50%,不全流产率30%;Ⅰ组完全流产率8.7%。NET与15-m-PGF_(2α)配伍的抗早孕效果优于TMX,且价格便宜,建议临床可推广使用。
The anti-early pregnancy effect of tamoxifen (TMX) or norethisterone (NET) with or without dl-15-methyl prostaglandin F_(2α) (l5-m-PGF_(2α)) was compared in 123 early pregnant women. The cases were divided into four groups: group 1,TMX alone; group 2. TMX with l5-m-PGF_(2α) suppository; group 3, TMX with 15-m-PGF_(2α) intramuscular injection; and group 4, NET with i5-m-PGF_(2α) injection. The most effective abortifacient combination was group 4. in which complete abortion rate was 95% (P<0.05, vs the other three groups) and incomplete abortion 3.3%; the second effective combination was of group 3, in which complete abortion rate was 85%. incomplete abortion rate 15%; the third, was group 2, complete and incomplete rates being 50 and 30%. respectively. In group 1, only 8.7% was complete abortion. From the results, we recommend NET combined with 15-m-PGF_(2α) injection as a choice in anti-early pregnancy regimen.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1992年第4期47-52,共6页
Reproduction and Contraception
关键词
三苯氧胺
炔诺酮
前列腺素
抗早孕
Tamoxifen, Norethisterone, Prostaglandin, Anti-early pregnancy
