摘要
将抗雌激素药物三苯氧胺(Tamoxifen,Tam)与dl-15-甲基-前列腺素F_(2a)(15-m-PGF2_(2a))联合使用抗早孕34例,其中8例用Tam前、后用放射免疫法作血清激素测定。在另一组18例早孕人工流产手术(人流术)妇女中,观察了Tam对绒毛及蜕膜组织的影响。结果:本组34例中31例(91.18％)完全流产,1例(2.94％)不完全流产,2例(5.88％)失败。用Tam后血清绒毛膜促进腺[激]素β亚单位(β-hCG)倍增时间明显延长,为7.854-1.52d(X±SE)。提示Tam可抑制早孕时hCG的分泌。用Tam后蜕膜组织胞浆和胞核的雌二醇(E_2)受体含量以及胞浆孕酮(P_0)受体含量下降不显著。
Tamoxifen(Tam)combined with dl-15-methyl prostaglandin F2α (l5-m-PGF2α) were used in 34 healthy women in early pregnancy requesting abortion. In 8 of them radioimmunoassay of serum hormones were done before and after Tam administration. In another group of 18 early pregnant women applying for abortion, Tam was given to 9 of them to study its effects on deoidual tissues, the remaining 9 cases had vacuum aspiration and served as controls. In 34 cases treated by Tam and dl-15-m-PGF2α, 31 (91.18%) resulted in complete abortion, 1(2.94%) imoomplete abortion and 2(6.88%) failed. The β-hCG doubling time was delayed markedly to 7.86±2.25 days (x±SE) after Tam administration, suggesting that Tam has inhibitory action on the secretion of β-hCG in early pregnancy. Deoidual oytoplasmio estradiol (E2), progesterone and nuclear E2 receptor levels showed statistically insignificant decrease, after Tam administration (P>0.05).
出处
《上海医科大学学报》
CSCD
1990年第5期378-381,共4页
Journal of Fudan University(Medical Science)
关键词
三苯氧胺
前列腺素
抗早孕
tamoxifen
prostaglandiu
termination of early pregnancy
