摘要
口服三苯氧胺和未服药的早孕妇女,经手术人工流产的胎盘绒毛组织,在无菌条件下进行体外培养。用RIA方法测定培液中孕酮和人绒毛膜促性腺激素(hCG)的含量。实验结果为:用药组孕酮、hCG的基础分泌量较未服药组显著为低(p<0.001)。促黄体素释放激素类似物(LHRH-A)能促进绒毛滋养层细胞孕酮、hCG的分泌,但用药组绒毛滋养层细胞对LHRH-A的反应性明显低于未服药对照组(p<0.01)。
The chorio-trophoblastic cells in early pregnant womentaking orally tamoxifen and without tamoxifen were cultured in vitrounder aseptic condition. All pregnant women were aborted by suction cure-ttage. The concentration of progestcrone and hCG in the cultured humantrophoblastic cells were assayed by the radioimmunoassay technique. Theresults showed that basal levels of progesterone and hCG secretions bychorio-trophoblastic cells in the tamoxifen-treated group were significantlylowered when compared with those in the untreated controls (p<0. 001).LHRH-A could increase the amount of progesterone and hCG secreted bythe chorio-trophoblastic cells. The response of chorio-trophoblastic cellsto LHRH-A in the tamoxifen treated group significantly decreased whencompared with that in the untreated group (p<0. 01).
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1991年第1期28-31,共4页
The Chinese Journal of Clinical Pharmacology
关键词
三苯氧胺
拮抗剂
孕酮
tamoxifen
placental chorio-trophoblastic cells
LHRHA
progesterone
hCG
